C57BL/6NTac-Kcnj11^em1H/H

Status	Available to order
EMMA ID	EM:12523
Citation information	RRID:IMSR_EM:12523 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57BL/6NTac-Kcnj11^em1H/H
Alternative name	KCNJ11-E23K-EM1-B6N
Strain type	Endonuclease-mediated
Allele/Transgene symbol	Kcnj11^em1H
Gene/Transgene symbol	Kcnj11

Information from provider

Provider	MRC-Harwell
Provider affiliation	Mary Lyon Centre at MRC Harwell
Genetic information	For detailed information on the genetic description of this strain, please have a look at this report.
Phenotypic information	Homozygous: Not known Heterozygous: None reported
Breeding history	Co-isogenic on original background
References	Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat.;Seki Takahiro, Hosaka Kayoko, Lim Sharon, Fischer Carina, Honek Jennifer, Yang Yunlong, Andersson Patrik, Nakamura Masaki, Näslund Erik, Ylä-Herttuala Seppo, Sun Meili, Iwamoto Hideki, Li Xuri, Liu Yizhi, Samani Nilesh J, Cao Yihai, ;2016;Nature communications;7;12152; 27492130
Homozygous fertile	yes
Homozygous viable	not known
Homozygous matings required	no
Immunocompromised	not known

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

DEND syndrome / Orphanet_79134
Intermediate DEND syndrome / Orphanet_99989
Autosomal dominant hyperinsulinism due to Kir6.2 deficiency / Orphanet_276580
Autosomal recessive hyperinsulinism due to Kir6.2 deficiency / Orphanet_79644
MODY / Orphanet_552
Diazoxide-resistant focal hyperinsulinism due to Kir6.2 deficiency / Orphanet_276603
Transient neonatal diabetes mellitus / Orphanet_99886
Permanent neonatal diabetes mellitus / Orphanet_99885

IMPC phenotypes (gene matching)

abnormal ear morphology / IMPC
decreased hemoglobin content / IMPC
impaired glucose tolerance / IMPC
decreased fasting circulating glucose level / IMPC

Literature references

Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat.;Seki Takahiro, Hosaka Kayoko, Lim Sharon, Fischer Carina, Honek Jennifer, Yang Yunlong, Andersson Patrik, Nakamura Masaki, Näslund Erik, Ylä-Herttuala Seppo, Sun Meili, Iwamoto Hideki, Li Xuri, Liu Yizhi, Samani Nilesh J, Cao Yihai, ;2016;Nature communications;7;12152; 27492130

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

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Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

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Legally binding conditions for the transfer

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C57BL/6NTac-Kcnj11em1H/H