C57BL/6NTac-Prkraem1(IMPC)H/H

Status

Available to order

EMMA IDEM:12482
International strain nameC57BL/6NTac-Prkraem1(IMPC)H/H
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolPrkraem1(IMPC)H
Gene/Transgene symbolPrkra

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (allele matching)
  • male infertility / IMPC
  • abnormal ear morphology / IMPC
  • decreased circulating alkaline phosphatase level / IMPC
  • increased circulating cholesterol level / IMPC
  • increased blood urea nitrogen level / IMPC
  • decreased prepulse inhibition / IMPC
  • increased grip strength / IMPC
  • increased freezing behavior / IMPC
IMPC phenotypes (gene matching)
  • decreased circulating alkaline phosphatase level / IMPC
  • abnormal ear morphology / IMPC
  • increased grip strength / IMPC
  • male infertility / IMPC
  • increased freezing behavior / IMPC
  • increased blood urea nitrogen level / IMPC
  • decreased prepulse inhibition / IMPC
  • increased circulating cholesterol level / IMPC
MGI phenotypes (gene matching)
  • small ears / MGI
  • abnormal middle ear morphology / MGI
  • abnormal neurocranium morphology / MGI
  • short snout / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • postnatal growth retardation / MGI
  • reduced fertility / MGI
  • infertility / MGI
  • female infertility / MGI
  • abnormal outer ear morphology / MGI
  • small interparietal bone / MGI
  • short nasal bone / MGI
  • turbinate hypoplasia / MGI
  • abnormal middle ear ossicle morphology / MGI
  • vision/eye phenotype / MGI
  • abnormal external auditory canal morphology / MGI
  • impaired hearing / MGI
  • embryonic lethality before implantation, complete penetrance / MGI
  • increased or absent threshold for auditory brainstem response / MGI
  • wide cranial sutures / MGI
  • round snout / MGI
  • small mandibular condyloid process / MGI
  • abnormal temporal bone zygomatic process morphology / MGI
  • small mandibular coronoid process / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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