C57BL/6NTac-Grm1em2(IMPC)H/H

Status

Available to order

EMMA IDEM:12463
Citation informationRRID:IMSR_EM:12463 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6NTac-Grm1em2(IMPC)H/H
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolGrm1em2(IMPC)H
Gene/Transgene symbolGrm1

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • Autosomal recessive congenital cerebellar ataxia due to MGLUR1 deficiency / Orphanet_324262
MGI phenotypes (gene matching)
  • increased brown adipose tissue amount / MGI
  • decreased bone mineral density / MGI
  • kyphoscoliosis / MGI
  • kyphosis / MGI
  • muscle spasm / MGI
  • tremors / MGI
  • weakness / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • abnormal maternal nurturing / MGI
  • ataxia / MGI
  • hypoactivity / MGI
  • abnormal gait / MGI
  • decreased exploration in new environment / MGI
  • abnormal spatial learning / MGI
  • abnormal contextual conditioning behavior / MGI
  • reduced long term potentiation / MGI
  • reduced long term depression / MGI
  • hunched posture / MGI
  • limb grasping / MGI
  • impaired righting response / MGI
  • impaired limb coordination / MGI
  • impaired balance / MGI
  • reduced fertility / MGI
  • reduced female fertility / MGI
  • male infertility / MGI
  • premature death / MGI
  • abnormal fertility/fecundity / MGI
  • abnormal nervous system electrophysiology / MGI
  • abnormal sexual interaction / MGI
  • albuminuria / MGI
  • abnormal excitatory postsynaptic currents / MGI
  • nervous system phenotype / MGI
  • abnormal proximal convoluted tubule morphology / MGI
  • increased susceptibility to injury / MGI
  • glomerulosclerosis / MGI
  • narrow eye opening / MGI
  • abnormal podocyte morphology / MGI
  • behavior/neurological phenotype / MGI
  • podocyte foot process effacement / MGI
  • decreased bone mineral content / MGI
  • abnormal renal glomerulus basement membrane morphology / MGI
  • renal cast / MGI
  • increased renal glomerulus basement membrane thickness / MGI
  • abnormal glomerular filtration barrier function / MGI
  • abnormal electroretinogram waveform feature / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).