- increased brown adipose tissue amount / MGI
- decreased bone mineral density / MGI
- kyphoscoliosis / MGI
- kyphosis / MGI
- muscle spasm / MGI
- tremors / MGI
- weakness / MGI
- decreased body weight / MGI
- decreased body size / MGI
- abnormal maternal nurturing / MGI
- ataxia / MGI
- hypoactivity / MGI
- abnormal gait / MGI
- decreased exploration in new environment / MGI
- abnormal spatial learning / MGI
- abnormal contextual conditioning behavior / MGI
- reduced long term potentiation / MGI
- reduced long term depression / MGI
- hunched posture / MGI
- limb grasping / MGI
- impaired righting response / MGI
- impaired limb coordination / MGI
- impaired balance / MGI
- reduced fertility / MGI
- reduced female fertility / MGI
- male infertility / MGI
- premature death / MGI
- abnormal fertility/fecundity / MGI
- abnormal nervous system electrophysiology / MGI
- abnormal sexual interaction / MGI
- albuminuria / MGI
- abnormal excitatory postsynaptic currents / MGI
- nervous system phenotype / MGI
- abnormal proximal convoluted tubule morphology / MGI
- increased susceptibility to injury / MGI
- glomerulosclerosis / MGI
- narrow eye opening / MGI
- abnormal podocyte morphology / MGI
- behavior/neurological phenotype / MGI
- podocyte foot process effacement / MGI
- decreased bone mineral content / MGI
- abnormal renal glomerulus basement membrane morphology / MGI
- renal cast / MGI
- increased renal glomerulus basement membrane thickness / MGI
- abnormal glomerular filtration barrier function / MGI
- abnormal electroretinogram waveform feature / MGI
C57BL/6NTac-Grm1em2(IMPC)H/H
Status | Available to order |
EMMA ID | EM:12463 |
International strain name | C57BL/6NTac-Grm1em2(IMPC)H/H |
Alternative name | |
Strain type | Endonuclease-mediated |
Allele/Transgene symbol | Grm1em2(IMPC)H |
Gene/Transgene symbol | Grm1 |
Information from provider
Provider | MRC, Medical Research Council |
Provider affiliation | Mary Lyon Centre at MRC Harwell |
Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal recessive congenital cerebellar ataxia due to MGLUR1 deficiency / Orphanet_324262
MGI phenotypes (gene matching)
Information on how we integrate external resources can be found here
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).