C57BL/6NTac-Adora2aem2(IMPC)H/H

Status

Available to order

EMMA IDEM:12438
International strain nameC57BL/6NTac-Adora2aem2(IMPC)H/H
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolAdora2aem2(IMPC)H
Gene/Transgene symbolAdora2a

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (gene matching)
  • increased total body fat amount / IMPC
  • increased circulating alanine transaminase level / IMPC
  • decreased hemoglobin content / IMPC
  • decreased lean body mass / IMPC
  • increased circulating glucose level / IMPC
  • decreased lymphocyte cell number / IMPC
  • decreased locomotor activity / IMPC
  • increased circulating aspartate transaminase level / IMPC
  • increased neutrophil cell number / IMPC
  • increased freezing behavior / IMPC
MGI phenotypes (gene matching)
  • heart right ventricle hypertrophy / MGI
  • abnormal pulmonary artery morphology / MGI
  • increased aggression towards males / MGI
  • increased anxiety-related response / MGI
  • hypoactivity / MGI
  • decreased exploration in new environment / MGI
  • abnormal liquid preference / MGI
  • abnormal cardiovascular system physiology / MGI
  • increased thermal nociceptive threshold / MGI
  • increased heart rate / MGI
  • abnormal sclera morphology / MGI
  • increased systemic arterial blood pressure / MGI
  • vascular smooth muscle hypertrophy / MGI
  • hypoalgesia / MGI
  • myopia / MGI
  • abnormal locomotor activation / MGI
  • pulmonary hypertension / MGI
  • nervous system phenotype / MGI
  • abnormal lung vasculature morphology / MGI
  • cardiovascular system phenotype / MGI
  • vision/eye phenotype / MGI
  • decreased cerebral infarction size / MGI
  • decreased susceptibility to ischemic brain injury / MGI
  • increased body mass index / MGI
  • decreased interleukin-10 secretion / MGI
  • decreased physiological sensitivity to xenobiotic / MGI
  • increased platelet aggregation / MGI
  • impaired behavioral response to addictive substance / MGI
  • impaired behavioral response to alcohol / MGI
  • increased right ventricle systolic pressure / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).