IMPC phenotypes (allele matching)
C57BL/6NTac-Rnf168em1(IMPC)H/H
| Status | Available to order |
| EMMA ID | EM:12429 |
| International strain name | C57BL/6NTac-Rnf168em1(IMPC)H/H |
| Alternative name | |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Rnf168em1(IMPC)H |
| Gene/Transgene symbol | Rnf168 |
Information from provider
| Provider | MRC, Medical Research Council |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- RIDDLE syndrome / Orphanet_420741
IMPC phenotypes (gene matching)
- increased mean platelet volume / IMPC
- abnormal spleen morphology / IMPC
- increased circulating creatine kinase level / IMPC
- vertebral fusion / IMPC
- increased circulating aspartate transaminase level / IMPC
- decreased hematocrit / IMPC
- abnormal cornea morphology / IMPC
- abnormal coat/hair pigmentation / IMPC
- increased circulating alanine transaminase level / IMPC
- increased grip strength / IMPC
- abnormal snout morphology / IMPC
- abnormal cranium morphology / IMPC
- fused cornea and lens / IMPC
- abnormal thymus morphology / IMPC
- abnormal head morphology / IMPC
- abnormal spine curvature / IMPC
- abnormal eye morphology / IMPC
- enlarged thymus / IMPC
- abnormal heart morphology / IMPC
- increased circulating lactate dehydrogenase level / IMPC
- microphthalmia / IMPC
- anophthalmia / IMPC
- decreased spleen weight / IMPC
- corneal opacity / IMPC
- abnormal skin morphology / IMPC
- enlarged heart / IMPC
- increased circulating phosphate level / IMPC
- increased eosinophil cell number / IMPC
- decreased body weight / IMPC
- decreased hemoglobin content / IMPC
- narrow eye opening / IMPC
- decreased erythrocyte cell number / IMPC