- decreased hematocrit / IMPC
- abnormal liver morphology / IMPC
- enlarged liver / IMPC
- abnormal spleen morphology / IMPC
- enlarged spleen / IMPC
- abnormal lens morphology / IMPC
- impaired righting response / IMPC
- increased circulating triglyceride level / IMPC
- male infertility / IMPC
- female infertility / IMPC
- decreased mean corpuscular volume / IMPC
- increased mean platelet volume / IMPC
- decreased hemoglobin content / IMPC
- increased circulating alanine transaminase level / IMPC
- increased circulating alkaline phosphatase level / IMPC
- abnormal heart left ventricle morphology / IMPC
- decreased circulating iron level / IMPC
- decreased T cell number / IMPC
- increased circulating cholesterol level / IMPC
- abnormal cholesterol homeostasis / IMPC
- increased circulating aspartate transaminase level / IMPC
- immune system phenotype / IMPC
- decreased circulating serum albumin level / IMPC
- increased circulating creatinine level / IMPC
- decreased mean corpuscular hemoglobin / IMPC
- increased cardiac muscle contractility / IMPC
- increased circulating potassium level / IMPC
- decreased circulating sodium level / IMPC
- decreased mean corpuscular hemoglobin concentration / IMPC
- decreased NK T cell number / IMPC
- decreased CD4-positive, alpha-beta T cell number / IMPC
- decreased CD8-positive, alpha-beta T cell number / IMPC
- decreased B-2 B cell number / IMPC
- increased red blood cell distribution width / IMPC
- abnormal retina blood vessel morphology / IMPC
- increased lung elastance / IMPC
- decreased CD4-negative NK T cell number / IMPC
- decreased memory-marker CD4-negative NK T cell number / IMPC
C57BL/6NCrl-Abcg8tm1b(KOMP)Wtsi/Ph
Status | Available to order |
EMMA ID | EM:12339 |
International strain name | C57BL/6NCrl-Abcg8tm1b(KOMP)Wtsi/Ph |
Alternative name | EPD0270_5_F04 |
Strain type | Targeted Mutant Strains |
Allele/Transgene symbol | Abcg8tm1b(KOMP)Wtsi |
Gene/Transgene symbol | Abcg8 |
Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
Provider | Institute of Molecular Genetics |
Provider affiliation | Department of Transgenic Models of Diseases, Institute of Molecular Genetics |
Genetic information | This mouse line originates from KOMP ES clone EPD0270_5_F04. For further details on the construction of this clone see the page at the IMPC portal. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele (Gt(ROSA)26Sortm1(ACTB-cre,-EGFP)Ics (MGI:5285392)). Click here for more information on KOMP final vectors. |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | Institute of Molecular Genetics, Prague, Czech Republic |
Animals used for archiving | heterozygous C57BL/6NCrl |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Sitosterolemia / Orphanet_2882
IMPC phenotypes (allele matching)
IMPC phenotypes (gene matching)
- decreased circulating serum albumin level / IMPC
- increased red blood cell distribution width / IMPC
- increased circulating creatinine level / IMPC
- abnormal liver morphology / IMPC
- increased cardiac muscle contractility / IMPC
- increased circulating aspartate transaminase level / IMPC
- increased circulating alkaline phosphatase level / IMPC
- increased circulating cholesterol level / IMPC
- immune system phenotype / IMPC
- decreased NK T cell number / IMPC
- enlarged spleen / IMPC
- increased circulating alanine transaminase level / IMPC
- increased lung elastance / IMPC
- enlarged liver / IMPC
- increased mean platelet volume / IMPC
- decreased mean corpuscular volume / IMPC
- abnormal spleen morphology / IMPC
- abnormal heart left ventricle morphology / IMPC
- decreased CD8-positive, alpha-beta T cell number / IMPC
- abnormal retina blood vessel morphology / IMPC
- decreased CD4-positive, alpha-beta T cell number / IMPC
- decreased mean corpuscular hemoglobin / IMPC
- abnormal cholesterol homeostasis / IMPC
- female infertility / IMPC
- abnormal lens morphology / IMPC
- impaired righting response / IMPC
- decreased circulating iron level / IMPC
- increased circulating triglyceride level / IMPC
- decreased mean corpuscular hemoglobin concentration / IMPC
- decreased memory-marker CD4-negative NK T cell number / IMPC
- male infertility / IMPC
- decreased circulating sodium level / IMPC
- decreased CD4-negative NK T cell number / IMPC
- decreased hematocrit / IMPC
- decreased T cell number / IMPC
- decreased B-2 B cell number / IMPC
- increased circulating potassium level / IMPC
- decreased hemoglobin content / IMPC
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