- decreased circulating creatinine level / IMPC
- preweaning lethality, complete penetrance / IMPC
- decreased prepulse inhibition / IMPC
- abnormal auditory brainstem response / IMPC
- abnormal gait / IMPC
- improved glucose tolerance / IMPC
- abnormal snout morphology / IMPC
- decreased respiratory quotient / IMPC
C57BL/6NTac-Hoxa2tm1(EGFP/Cre/ERT2)Wtsi/Ics
Status | Available to order |
EMMA ID | EM:12333 |
International strain name | C57BL/6NTac-Hoxa2tm1(EGFP/Cre/ERT2)Wtsi/Ics |
Alternative name | CEPD0031_3_A05 |
Strain type | Targeted Mutant Strains : Knock-in |
Allele/Transgene symbol | Hoxa2tm1(EGFP/Cre/ERT2)Wtsi |
Gene/Transgene symbol | Hoxa2 |
Information from provider
Provider | ICS, Institut Clinique de la Souris |
Provider affiliation | ICS, Institut Clinique de la Souris |
Genetic information | This mouse line originates from EUCOMM ES clone CEPD0031_3_A05. For further details on the construction of this clone see the page at the IMPC portal. Quality Control/Disclaimer: The structure of the targeted mutation is not fully verified. It is recommended that the recipient confirms the mutation structure by Southern blotting. The Cre expression pattern is expected to mirror that of the host gene, but this may not be fully described and/or may be modified in the targeted allele. Although characterisation of the Cre expression pattern is an objective of EUCOMMTools this is an ongoing process which may be incomplete. It is therefore recommended that the recipient verifies the Cre expression pattern. For the tm1(EGFP/Cre/ERT2) type allele, if the promoter-driven selection cassette is flanked with Rox sites, it may be removed using Dre recombinase. Please be aware that the strain description may be subject to change. For the most recent description please consult the information pages for the appropriate product details at the IMPC portal. |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Bilateral microtia-deafness-cleft palate syndrome / Orphanet_140963
- Microtia / Orphanet_83463
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- abnormal malleus morphology / MGI
- abnormal tympanic ring morphology / MGI
- abnormal otic capsule morphology / MGI
- abnormal basioccipital bone morphology / MGI
- abnormal basisphenoid bone morphology / MGI
- cleft palate / MGI
- abnormal cartilage development / MGI
- abnormal craniofacial morphology / MGI
- abnormal cranium morphology / MGI
- abnormal facial motor nucleus morphology / MGI
- abnormal brain development / MGI
- abnormal rhombomere morphology / MGI
- decreased sensory neuron number / MGI
- abnormal facial nerve morphology / MGI
- abnormal glossopharyngeal nerve morphology / MGI
- abnormal vagus nerve morphology / MGI
- abnormal suckling behavior / MGI
- aphagia / MGI
- postnatal growth retardation / MGI
- abnormal ear morphology / MGI
- abnormal skeleton development / MGI
- abnormal craniofacial bone morphology / MGI
- no abnormal phenotype detected / MGI
- abnormal outer ear morphology / MGI
- abnormal hyoid bone morphology / MGI
- absent malleus processus brevis / MGI
- abnormal scala vestibuli morphology / MGI
- nervous system phenotype / MGI
- abnormal nervous system morphology / MGI
- abnormal tongue muscle morphology / MGI
- absent stapes / MGI
- abnormal temporal bone squamous part morphology / MGI
- abnormal stapedial artery morphology / MGI
- absent stapedial artery / MGI
- abnormal behavior / MGI
- abnormal middle ear ossicle morphology / MGI
- abnormal incus morphology / MGI
- abnormal stapes morphology / MGI
- abnormal temporal bone morphology / MGI
- hearing/vestibular/ear phenotype / MGI
- abnormal skeleton morphology / MGI
- absent outer ear / MGI
- abnormal Meckel's cartilage morphology / MGI
- abnormal tympanic membrane morphology / MGI
- abnormal external auditory canal morphology / MGI
- abnormal styloid process morphology / MGI
- small malleus processus brevis / MGI
- abnormal gonial bone morphology / MGI
- enlarged gonial bone / MGI
- absent styloid process / MGI
- meteorism / MGI
- cleft secondary palate / MGI
- bifid tongue / MGI
- abnormal hyoid bone lesser horn morphology / MGI
- absent hyoid bone lesser horns / MGI
- abnormal neuron differentiation / MGI
- increased oligodendrocyte progenitor number / MGI
- lethality at weaning, complete penetrance / MGI
- neonatal lethality, complete penetrance / MGI
- increased rhombomere 1 size / MGI
- abnormal rhombomere 2 morphology / MGI
- abnormal rhombomere 3 morphology / MGI
- decreased rhombomere 3 size / MGI
- abnormal rhombomere boundary morphology / MGI
- abnormal incudostapedial joint morphology / MGI
- abnormal retrotympanic process morphology / MGI
- absent stylohyoid muscle / MGI
- abnormal tympanic cavity morphology / MGI
- absent stapedius muscle / MGI
- abnormal tensor tympani muscle morphology / MGI
- abnormal styloglossus muscle morphology / MGI
- abnormal tubotympanic recess morphology / MGI
- abnormal temporal bone tympanic part morphology / MGI
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