C57BL/6NTac-Hoxa2tm1(EGFP/Cre/ERT2)Wtsi/Ics

Status

Available to order

EMMA IDEM:12333
International strain nameC57BL/6NTac-Hoxa2tm1(EGFP/Cre/ERT2)Wtsi/Ics
Alternative nameCEPD0031_3_A05
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolHoxa2tm1(EGFP/Cre/ERT2)Wtsi
Gene/Transgene symbolHoxa2

Information from provider

Provider ICS, Institut Clinique de la Souris
Provider affiliationICS, Institut Clinique de la Souris
Genetic informationThis mouse line originates from EUCOMM ES clone CEPD0031_3_A05. For further details on the construction of this clone see the page at the IMPC portal.
Quality Control/Disclaimer: The structure of the targeted mutation is not fully verified. It is recommended that the recipient confirms the mutation structure by Southern blotting. The Cre expression pattern is expected to mirror that of the host gene, but this may not be fully described and/or may be modified in the targeted allele. Although characterisation of the Cre expression pattern is an objective of EUCOMMTools this is an ongoing process which may be incomplete. It is therefore recommended that the recipient verifies the Cre expression pattern. For the tm1(EGFP/Cre/ERT2) type allele, if the promoter-driven selection cassette is flanked with Rox sites, it may be removed using Dre recombinase. Please be aware that the strain description may be subject to change. For the most recent description please consult the information pages for the appropriate product details at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • decreased circulating creatinine level / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • decreased prepulse inhibition / IMPC
  • abnormal auditory brainstem response / IMPC
  • abnormal gait / IMPC
  • improved glucose tolerance / IMPC
  • abnormal snout morphology / IMPC
  • decreased respiratory quotient / IMPC
MGI phenotypes (gene matching)
  • abnormal malleus morphology / MGI
  • abnormal tympanic ring morphology / MGI
  • abnormal otic capsule morphology / MGI
  • abnormal basioccipital bone morphology / MGI
  • abnormal basisphenoid bone morphology / MGI
  • cleft palate / MGI
  • abnormal cartilage development / MGI
  • abnormal craniofacial morphology / MGI
  • abnormal cranium morphology / MGI
  • abnormal facial motor nucleus morphology / MGI
  • abnormal brain development / MGI
  • abnormal rhombomere morphology / MGI
  • decreased sensory neuron number / MGI
  • abnormal facial nerve morphology / MGI
  • abnormal glossopharyngeal nerve morphology / MGI
  • abnormal vagus nerve morphology / MGI
  • abnormal suckling behavior / MGI
  • aphagia / MGI
  • postnatal growth retardation / MGI
  • abnormal ear morphology / MGI
  • abnormal skeleton development / MGI
  • abnormal craniofacial bone morphology / MGI
  • no abnormal phenotype detected / MGI
  • abnormal outer ear morphology / MGI
  • abnormal hyoid bone morphology / MGI
  • absent malleus processus brevis / MGI
  • abnormal scala vestibuli morphology / MGI
  • nervous system phenotype / MGI
  • abnormal nervous system morphology / MGI
  • abnormal tongue muscle morphology / MGI
  • absent stapes / MGI
  • abnormal temporal bone squamous part morphology / MGI
  • abnormal stapedial artery morphology / MGI
  • absent stapedial artery / MGI
  • abnormal behavior / MGI
  • abnormal middle ear ossicle morphology / MGI
  • abnormal incus morphology / MGI
  • abnormal stapes morphology / MGI
  • abnormal temporal bone morphology / MGI
  • hearing/vestibular/ear phenotype / MGI
  • abnormal skeleton morphology / MGI
  • absent outer ear / MGI
  • abnormal Meckel's cartilage morphology / MGI
  • abnormal tympanic membrane morphology / MGI
  • abnormal external auditory canal morphology / MGI
  • abnormal styloid process morphology / MGI
  • small malleus processus brevis / MGI
  • abnormal gonial bone morphology / MGI
  • enlarged gonial bone / MGI
  • absent styloid process / MGI
  • meteorism / MGI
  • cleft secondary palate / MGI
  • bifid tongue / MGI
  • abnormal hyoid bone lesser horn morphology / MGI
  • absent hyoid bone lesser horns / MGI
  • abnormal neuron differentiation / MGI
  • increased oligodendrocyte progenitor number / MGI
  • lethality at weaning, complete penetrance / MGI
  • neonatal lethality, complete penetrance / MGI
  • increased rhombomere 1 size / MGI
  • abnormal rhombomere 2 morphology / MGI
  • abnormal rhombomere 3 morphology / MGI
  • decreased rhombomere 3 size / MGI
  • abnormal rhombomere boundary morphology / MGI
  • abnormal incudostapedial joint morphology / MGI
  • abnormal retrotympanic process morphology / MGI
  • absent stylohyoid muscle / MGI
  • abnormal tympanic cavity morphology / MGI
  • absent stapedius muscle / MGI
  • abnormal tensor tympani muscle morphology / MGI
  • abnormal styloglossus muscle morphology / MGI
  • abnormal tubotympanic recess morphology / MGI
  • abnormal temporal bone tympanic part morphology / MGI

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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