IMPC phenotypes (gene matching)
C57BL/6NTac-Pthtm2(EGFP/Cre/ERT2)Wtsi/Ics
| Status | Available to order |
| EMMA ID | EM:12319 |
| International strain name | C57BL/6NTac-Pthtm2(EGFP/Cre/ERT2)Wtsi/Ics |
| Alternative name | CEPD0086_5_A10 |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Pthtm2(EGFP/Cre/ERT2)Wtsi |
| Gene/Transgene symbol | Pth |
Information from provider
| Provider | ICS, Institut Clinique de la Souris |
| Provider affiliation | ICS, Institut Clinique de la Souris |
| Genetic information | This mouse line originates from EUCOMM ES clone CEPD0086_5_A10. For further details on the construction of this clone see the page at the IMPC portal. Quality Control/Disclaimer: The structure of the targeted mutation is not fully verified. It is recommended that the recipient confirms the mutation structure by Southern blotting. The Cre expression pattern is expected to mirror that of the host gene, but this may not be fully described and/or may be modified in the targeted allele. Although characterisation of the Cre expression pattern is an objective of EUCOMMTools this is an ongoing process which may be incomplete. It is therefore recommended that the recipient verifies the Cre expression pattern. For the tm2(EGFP/Cre/ERT2) type allele, if the promoter-driven selection cassette is flanked with Rox sites, it may be removed using Dre recombinase. Please be aware that the strain description may be subject to change. For the most recent description please consult the information pages for the appropriate product details at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Familial isolated hypoparathyroidism due to impaired PTH secretion / Orphanet_189466
MGI phenotypes (gene matching)
- abnormal trabecular bone morphology / MGI
- abnormal cartilage development / MGI
- abnormal angiogenesis / MGI
- abnormal cranium morphology / MGI
- abnormal skeleton development / MGI
- abnormal bone mineralization / MGI
- enlarged parathyroid gland / MGI
- increased width of hypertrophic chondrocyte zone / MGI
- abnormal bone structure / MGI
- increased compact bone thickness / MGI
- short metacarpal bones / MGI
- short metatarsal bones / MGI
- small vertebral body / MGI
- decreased length of long bones / MGI
- abnormal osteoclast morphology / MGI
- decreased osteoclast cell number / MGI
- decreased osteoblast cell number / MGI
- increased osteoblast apoptosis / MGI
- increased osteocyte apoptosis / MGI