C57BL/6NTac-Cidectm1(EGFP/Cre/ERT2)Wtsi/Ics

Status

Available to order

EMMA IDEM:12307
International strain nameC57BL/6NTac-Cidectm1(EGFP/Cre/ERT2)Wtsi/Ics
Alternative nameCEPD0070_2_A06
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolCidectm1(EGFP/Cre/ERT2)Wtsi
Gene/Transgene symbolCidec

Information from provider

Provider ICS, Institut Clinique de la Souris
Provider affiliationICS, Institut Clinique de la Souris
Genetic informationThis mouse line originates from EUCOMM ES clone CEPD0070_2_A06. For further details on the construction of this clone see the page at the IMPC portal.
Quality Control/Disclaimer: The structure of the targeted mutation is not fully verified. It is recommended that the recipient confirms the mutation structure by Southern blotting. The Cre expression pattern is expected to mirror that of the host gene, but this may not be fully described and/or may be modified in the targeted allele. Although characterisation of the Cre expression pattern is an objective of EUCOMMTools this is an ongoing process which may be incomplete. It is therefore recommended that the recipient verifies the Cre expression pattern. For the tm1(EGFP/Cre/ERT2) type allele, if the promoter-driven selection cassette is flanked with Rox sites, it may be removed using Dre recombinase. Please be aware that the strain description may be subject to change. For the most recent description please consult the information pages for the appropriate product details at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • increased fasting circulating glucose level / IMPC
  • decreased total body fat amount / IMPC
  • increased lean body mass / IMPC
  • decreased circulating alkaline phosphatase level / IMPC
  • persistence of hyaloid vascular system / IMPC
  • abnormal optic disk morphology / IMPC
  • abnormal auditory brainstem response / IMPC
  • increased circulating cholesterol level / IMPC
  • increased mean corpuscular volume / IMPC
MGI phenotypes (gene matching)
  • decreased white adipose tissue amount / MGI
  • no abnormal phenotype detected / MGI
  • decreased susceptibility to hepatic steatosis / MGI
  • decreased circulating triglyceride level / MGI
  • decreased circulating free fatty acid level / MGI
  • increased insulin sensitivity / MGI
  • abnormal white adipose tissue morphology / MGI
  • abnormal brown adipose tissue morphology / MGI
  • decreased susceptibility to age related obesity / MGI
  • decreased circulating ketone body level / MGI
  • increased energy expenditure / MGI
  • increased oxygen consumption / MGI
  • improved glucose tolerance / MGI
  • abnormal fat pad morphology / MGI
  • abnormal gonadal fat pad morphology / MGI
  • vision/eye phenotype / MGI
  • increased body temperature / MGI
  • decreased circulating glucose level / MGI
  • decreased susceptibility to diet-induced obesity / MGI
  • decreased circulating leptin level / MGI
  • enhanced lipolysis / MGI
  • decreased subcutaneous adipose tissue amount / MGI
  • abnormal fat cell morphology / MGI
  • decreased gonadal fat pad weight / MGI
  • decreased inguinal fat pad weight / MGI
  • decreased mesenteric fat pad weight / MGI
  • decreased retroperitoneal fat pad weight / MGI
  • abnormal blood homeostasis / MGI
  • decreased total body fat amount / MGI
  • increased respiratory quotient / MGI
  • integument phenotype / MGI
  • impaired adaptive thermogenesis / MGI
  • increased food intake / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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