IMPC phenotypes (gene matching)
C57BL/6NTac-Pdgfrbtm1(EGFP/Cre/ERT2)Wtsi/Ics
| Status | Available to order |
| EMMA ID | EM:12306 |
| International strain name | C57BL/6NTac-Pdgfrbtm1(EGFP/Cre/ERT2)Wtsi/Ics |
| Alternative name | CEPD0063_5_A02 |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Pdgfrbtm1(EGFP/Cre/ERT2)Wtsi |
| Gene/Transgene symbol | Pdgfrb |
Information from provider
| Provider | ICS, Institut Clinique de la Souris |
| Provider affiliation | ICS, Institut Clinique de la Souris |
| Genetic information | This mouse line originates from EUCOMM ES clone CEPD0063_5_A02. For further details on the construction of this clone see the page at the IMPC portal. Quality Control/Disclaimer: The structure of the targeted mutation is not fully verified. It is recommended that the recipient confirms the mutation structure by Southern blotting. The Cre expression pattern is expected to mirror that of the host gene, but this may not be fully described and/or may be modified in the targeted allele. Although characterisation of the Cre expression pattern is an objective of EUCOMMTools this is an ongoing process which may be incomplete. It is therefore recommended that the recipient verifies the Cre expression pattern. For the tm1(EGFP/Cre/ERT2) type allele, if the promoter-driven selection cassette is flanked with Rox sites, it may be removed using Dre recombinase. Please be aware that the strain description may be subject to change. For the most recent description please consult the information pages for the appropriate product details at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Acroosteolysis-keloid-like lesions-premature aging syndrome / Orphanet_363665
- Skeletal overgrowth-craniofacial dysmorphism-hyperelastic skin-white matter lesions syndrome / Orphanet_477831
- Infantile myofibromatosis / Orphanet_2591
- Bilateral striopallidodentate calcinosis / Orphanet_1980
MGI phenotypes (gene matching)
- abnormal angiogenesis / MGI
- abnormal heart morphology / MGI
- overriding aortic valve / MGI
- enlarged heart / MGI
- double outlet right ventricle / MGI
- schistocytosis / MGI
- short snout / MGI
- abnormal pulmonary artery morphology / MGI
- abnormal kidney blood vessel morphology / MGI
- kidney hemorrhage / MGI
- decreased body size / MGI
- anemia / MGI
- abnormal blood vessel morphology / MGI
- thymus hypoplasia / MGI
- hemorrhage / MGI
- intracranial hemorrhage / MGI
- perinatal lethality / MGI
- abnormal eye morphology / MGI
- abnormal kidney physiology / MGI
- no abnormal phenotype detected / MGI
- disorganized myocardium / MGI
- hydrops fetalis / MGI
- abnormal erythrocyte morphology / MGI
- micrognathia / MGI
- anisocytosis / MGI
- poikilocytosis / MGI
- dilated heart right ventricle / MGI
- abnormal retinal vasculature morphology / MGI
- increased vascular permeability / MGI
- retinal detachment / MGI
- dilated heart atrium / MGI
- cardiac fibrosis / MGI
- thrombocytopenia / MGI
- abnormal placenta vasculature / MGI
- abnormal embryonic hematopoiesis / MGI
- kidney cysts / MGI
- pallor / MGI
- abnormal pericyte morphology / MGI
- abnormal retinal layer morphology / MGI
- abnormal heart left ventricle morphology / MGI
- abnormal venule morphology / MGI
- right aortic arch / MGI
- abnormal basement membrane morphology / MGI
- abnormal trophoblast layer morphology / MGI
- polychromatophilia / MGI
- increased susceptibility to injury / MGI
- glomerulosclerosis / MGI
- abnormal renal glomerulus morphology / MGI
- abnormal mesangial cell morphology / MGI
- renal/urinary system phenotype / MGI
- homeostasis/metabolism phenotype / MGI
- cardiovascular system phenotype / MGI
- vision/eye phenotype / MGI
- decreased angiogenesis / MGI
- abnormal vascular endothelial cell morphology / MGI
- increased vascular endothelial cell number / MGI
- retinal hemorrhage / MGI
- eye hemorrhage / MGI
- clinodactyly / MGI
- decreased retinal ganglion cell number / MGI
- retinal ganglion cell degeneration / MGI
- absent podocytes / MGI
- increased heart ventricle size / MGI
- abnormal placental labyrinth vasculature morphology / MGI
- petechiae / MGI
- increased nucleated erythrocyte cell number / MGI
- eye opacity / MGI
- abnormal retinal blood vessel morphology / MGI
- abnormal retinal blood vessel pattern / MGI
- ventricular septal defect / MGI
- atrioventricular septal defect / MGI
- perimembraneous ventricular septal defect / MGI
- muscular ventricular septal defect / MGI
- kidney microaneurysm / MGI
- vascular ring / MGI
- abnormal left subclavian artery morphology / MGI
- postnatal lethality, incomplete penetrance / MGI
- perinatal lethality, incomplete penetrance / MGI
- lethality throughout fetal growth and development, incomplete penetrance / MGI
- decreased glomerular capillary number / MGI
- absent mesangial cell / MGI
- glomerulus hemorrhage / MGI
- decreased kidney cell proliferation / MGI
- glomerular capillary thrombosis / MGI
- skin hemorrhage / MGI
- purpura / MGI
- decreased fibroblast proliferation / MGI
- abnormal fibroblast migration / MGI
- decreased fibroblast apoptosis / MGI
- abnormal blood-retinal barrier function / MGI
- increased retinal apoptosis / MGI