IMPC phenotypes (gene matching)
C57BL/6NTac-Rbfox3tm1(EGFP/Cre/ERT2)Wtsi/Ics
| Status | Available to order |
| EMMA ID | EM:12292 |
| International strain name | C57BL/6NTac-Rbfox3tm1(EGFP/Cre/ERT2)Wtsi/Ics |
| Alternative name | CEPD0071_2_A09 |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Rbfox3tm1(EGFP/Cre/ERT2)Wtsi |
| Gene/Transgene symbol | Rbfox3 |
Information from provider
| Provider | ICS, Institut Clinique de la Souris |
| Provider affiliation | ICS, Institut Clinique de la Souris |
| Genetic information | This mouse line originates from EUCOMM ES clone CEPD0071_2_A09. For further details on the construction of this clone see the page at the IMPC portal. Quality Control/Disclaimer: The structure of the targeted mutation is not fully verified. It is recommended that the recipient confirms the mutation structure by Southern blotting. The Cre expression pattern is expected to mirror that of the host gene, but this may not be fully described and/or may be modified in the targeted allele. Although characterisation of the Cre expression pattern is an objective of EUCOMMTools this is an ongoing process which may be incomplete. It is therefore recommended that the recipient verifies the Cre expression pattern. For the tm1(EGFP/Cre/ERT2) type allele, if the promoter-driven selection cassette is flanked with Rox sites, it may be removed using Dre recombinase. Please be aware that the strain description may be subject to change. For the most recent description please consult the information pages for the appropriate product details at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
Disease and phenotype information
MGI phenotypes (gene matching)
- decreased anxiety-related response / MGI
- hyperactivity / MGI
- abnormal object recognition memory / MGI
- reduced long term depression / MGI
- impaired synaptic plasticity / MGI
- decreased brain weight / MGI
- abnormal CNS synaptic transmission / MGI
- abnormal thermal nociception / MGI
- increased susceptibility to pharmacologically induced seizures / MGI
- abnormal excitatory postsynaptic potential / MGI
- decreased paired-pulse facilitation / MGI
- nervous system phenotype / MGI
- abnormal miniature excitatory postsynaptic currents / MGI
- decreased neuronal precursor cell number / MGI
- behavior/neurological phenotype / MGI
- abnormal brain white matter morphology / MGI
- increased neurotransmitter release / MGI
- abnormal miniature inhibitory postsynaptic currents / MGI
- increased sensitivity to xenobiotic induced morbidity/mortality / MGI
- abnormal dendritic spine morphology / MGI
- abnormal neuron differentiation / MGI
- abnormal hippocampus granule cell morphology / MGI
- abnormal hippocampus neuron morphology / MGI
- abnormal hippocampus physiology / MGI
- impaired spatial learning / MGI
- abnormal dentate gyrus neuron dendrite morphology / MGI
- abnormal excitatory synapse morphology / MGI
- decreased neuronal precursor proliferation / MGI