IMPC phenotypes (gene matching)
- abnormal kidney morphology / IMPC
C57BL/6-Tgm3Gt(IST12449B1)Tigm/Cnrm
| Status | Available to order |
| EMMA ID | EM:12275 |
| Citation information | RRID:IMSR_EM:12275 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6-Tgm3Gt(IST12449B1)Tigm/Cnrm |
| Alternative name | TG3KO - C57Bl6 background |
| Strain type | Gene-trap |
| Allele/Transgene symbol | Tgm3Gt(IST12449B1)Tigm |
| Gene/Transgene symbol | Tgm3 |
Information from provider
| Provider | Eleonora Candi |
| Provider affiliation | Medicina Sperimentale, Università di Roma Tor Vergata |
| Genetic information | Homozygous Tgm3 gene trap (viable knock out) |
| Phenotypic information | Homozygous:TG3KO mice are viable and fertile. Tgm3 ablation affected partially hair development, no skin formation and gross barrier function defects were observed, but an increased sensitivity to UV photodamage was reported (Frezza V et al, 2017)Heterozygous:None |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Literature references
- Transglutaminase 3 Protects against Photodamage.;Frezza Valentina, Terrinoni Alessandro, Pitolli Consuelo, Mauriello Alessandro, Melino Gerry, Candi Eleonora, ;2017;The Journal of investigative dermatology;137;1590-1594; 28315658