IMPC phenotypes (gene matching)
B6D2F1 x B6-Cdkn1aem1(IMPC)Cnrm/Cnrm
| Status | Available to order |
| EMMA ID | EM:12215 |
| Citation information | RRID:IMSR_EM:12215 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6D2F1 x B6-Cdkn1aem1(IMPC)Cnrm/Cnrm |
| Alternative name | |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Cdkn1aem1(IMPC)Cnrm |
| Gene/Transgene symbol | Cdkn1a |
Information from provider
| Provider | CNR, Consiglio Nazionale delle Ricerche |
| Provider affiliation | EMMA-Monterotondo Campus International Development, CNR, Consiglio Nazionale delle Ricerche |
| Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
| Breeding at archiving centre | CRISPR/Cas-mediated conditional mutation. Cdkn1a critical exon 2 is flanked by two loxP sites, following their CRISPR/Cas-mediated, targeted insertion. Background strains: Zygote donor strain: 50% C57BL/6N + 50% DBA/2 (B6D2F1); Backcross strain: C57BL/6N; F3 mice are ca. 93.7% C57BL/6N + 6.3% DBA/2. Strain synonym: P21 conditional |
Disease and phenotype information
MGI phenotypes (gene matching)
- increased brown adipose tissue amount / MGI
- decreased monocyte cell number / MGI
- increased cell proliferation / MGI
- abnormal awl hair morphology / MGI
- abnormal auchene hair morphology / MGI
- enlarged spleen / MGI
- spleen hyperplasia / MGI
- enlarged lymph nodes / MGI
- decreased sensitivity to skin irradiation / MGI
- increased body weight / MGI
- decreased body weight / MGI
- increased metastatic potential / MGI
- increased cellular sensitivity to gamma-irradiation / MGI
- increased malignant tumor incidence / MGI
- abnormal tumor incidence / MGI
- increased tumor incidence / MGI
- increased B cell derived lymphoma incidence / MGI
- increased T cell derived lymphoma incidence / MGI
- increased carcinoma incidence / MGI
- premature death / MGI
- increased brain weight / MGI
- abnormal bone marrow cell morphology/development / MGI
- abnormal CD4-positive, alpha beta T cell morphology / MGI
- hepatic steatosis / MGI
- glomerulonephritis / MGI
- increased urine protein level / MGI
- decreased mortality induced by ionizing radiation / MGI
- altered response to CNS ischemic injury / MGI
- abnormal cell cycle / MGI
- increased hepatocellular carcinoma incidence / MGI
- decreased susceptibility to induced arthritis / MGI
- abnormal keratinocyte physiology / MGI
- kidney failure / MGI
- increased hemangiosarcoma incidence / MGI
- increased autoantibody level / MGI
- abnormal thymus physiology / MGI
- impaired macrophage chemotaxis / MGI
- increased kidney weight / MGI
- abnormal chromosome number / MGI
- abnormal cell cycle checkpoint function / MGI
- increased squamous cell carcinoma incidence / MGI
- increased incidence of tumors by chemical induction / MGI
- increased incidence of tumors by ionizing radiation induction / MGI
- decreased incidence of tumors by ionizing radiation induction / MGI
- increased anti-double stranded DNA antibody level / MGI
- increased anti-single stranded DNA antibody level / MGI
- increased anti-nuclear antigen antibody level / MGI
- increased anti-histone antibody level / MGI
- increased hematopoietic stem cell number / MGI
- decreased seminal vesicle weight / MGI
- abnormal neuronal precursor proliferation / MGI
- increased spleen weight / MGI
- decreased prostate gland weight / MGI
- increased neuronal precursor cell number / MGI
- abnormal self tolerance / MGI
- increased B cell number / MGI
- increased circulating cholesterol level / MGI
- increased T cell proliferation / MGI
- homeostasis/metabolism phenotype / MGI
- hearing/vestibular/ear phenotype / MGI
- growth/size/body region phenotype / MGI
- cardiovascular system phenotype / MGI
- immune system phenotype / MGI
- abnormal skin physiology / MGI
- abnormal cell physiology / MGI
- delayed cellular replicative senescence / MGI
- increased memory T cell number / MGI
- abnormal DNA replication / MGI
- lymph node hyperplasia / MGI
- increased cellular sensitivity to ultraviolet irradiation / MGI
- increased IgG1 level / MGI
- decreased zigzag hair amount / MGI
- enlarged cervical lymph nodes / MGI
- increased lung carcinoma incidence / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- increased sensitivity to induced cell death / MGI
- increased neuron number / MGI
- increased white fat cell number / MGI
- increased inguinal fat pad weight / MGI
- increased parametrial fat pad weight / MGI
- increased histiocytic sarcoma incidence / MGI
- abnormal prostate gland dorsolateral lobe morphology / MGI
- increased Leydig cell tumor incidence / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- increased sensitivity to xenobiotic induced morbidity/mortality / MGI
- decreased lymphoma incidence / MGI
- increased urinary system tumor incidence / MGI
- increased skin tumor incidence / MGI
- abnormal hematopoietic stem cell physiology / MGI
- increased fibroblast proliferation / MGI
- increased sebaceous gland adenoma incidence / MGI
- abnormal junctional epithelium morphology / MGI