IMPC phenotypes (gene matching)
B6D2F1 x B6-Cdkn1aem2(IMPC)Cnrm/Cnrm
| Status | Available to order |
| EMMA ID | EM:12214 |
| International strain name | B6D2F1 x B6-Cdkn1aem2(IMPC)Cnrm/Cnrm |
| Alternative name | |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Cdkn1aem2(IMPC)Cnrm |
| Gene/Transgene symbol | Cdkn1a |
Information from provider
| Provider | CNR, Consiglio Nazionale delle Ricerche |
| Provider affiliation | EMMA-Monterotondo Campus International Development, CNR, Consiglio Nazionale delle Ricerche |
| Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
| Breeding at archiving centre | CRISPR/Cas-mediated deletion of Cdkn1a critical exon 2. Background strains: Zygote donor strain: 50% C57BL/6N + 50% DBA/2 (B6D2F1); Backcross strain: C57BL/6N; F2 mice are ca. 87.5% C57BL/6N + 12.5% DBA/2. Strain synonym: P21 Knock-out. |
Disease and phenotype information
MGI phenotypes (gene matching)
- increased brown adipose tissue amount / MGI
- decreased monocyte cell number / MGI
- increased cell proliferation / MGI
- abnormal awl hair morphology / MGI
- abnormal auchene hair morphology / MGI
- enlarged spleen / MGI
- spleen hyperplasia / MGI
- enlarged lymph nodes / MGI
- decreased sensitivity to skin irradiation / MGI
- increased body weight / MGI
- decreased body weight / MGI
- increased metastatic potential / MGI
- increased cellular sensitivity to gamma-irradiation / MGI
- increased malignant tumor incidence / MGI
- abnormal tumor incidence / MGI
- increased tumor incidence / MGI
- increased B cell derived lymphoma incidence / MGI
- increased T cell derived lymphoma incidence / MGI
- increased carcinoma incidence / MGI
- premature death / MGI
- increased brain weight / MGI
- abnormal bone marrow cell morphology/development / MGI
- abnormal CD4-positive, alpha beta T cell morphology / MGI
- hepatic steatosis / MGI
- glomerulonephritis / MGI
- increased urine protein level / MGI
- decreased mortality induced by ionizing radiation / MGI
- altered response to CNS ischemic injury / MGI
- abnormal cell cycle / MGI
- increased hepatocellular carcinoma incidence / MGI
- decreased susceptibility to induced arthritis / MGI
- abnormal keratinocyte physiology / MGI
- kidney failure / MGI
- increased hemangiosarcoma incidence / MGI
- increased autoantibody level / MGI
- abnormal thymus physiology / MGI
- impaired macrophage chemotaxis / MGI
- increased kidney weight / MGI
- abnormal chromosome number / MGI
- abnormal cell cycle checkpoint function / MGI
- increased squamous cell carcinoma incidence / MGI
- increased incidence of tumors by chemical induction / MGI
- increased incidence of tumors by ionizing radiation induction / MGI
- decreased incidence of tumors by ionizing radiation induction / MGI
- increased anti-double stranded DNA antibody level / MGI
- increased anti-single stranded DNA antibody level / MGI
- increased anti-nuclear antigen antibody level / MGI
- increased anti-histone antibody level / MGI
- increased hematopoietic stem cell number / MGI
- decreased seminal vesicle weight / MGI
- abnormal neuronal precursor proliferation / MGI
- increased spleen weight / MGI
- decreased prostate gland weight / MGI
- increased neuronal precursor cell number / MGI
- abnormal self tolerance / MGI
- increased B cell number / MGI
- increased circulating cholesterol level / MGI
- increased T cell proliferation / MGI
- homeostasis/metabolism phenotype / MGI
- hearing/vestibular/ear phenotype / MGI
- growth/size/body region phenotype / MGI
- cardiovascular system phenotype / MGI
- immune system phenotype / MGI
- abnormal skin physiology / MGI
- abnormal cell physiology / MGI
- delayed cellular replicative senescence / MGI
- increased memory T cell number / MGI
- abnormal DNA replication / MGI
- lymph node hyperplasia / MGI
- increased cellular sensitivity to ultraviolet irradiation / MGI
- increased IgG1 level / MGI
- decreased zigzag hair amount / MGI
- enlarged cervical lymph nodes / MGI
- increased lung carcinoma incidence / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- increased sensitivity to induced cell death / MGI
- increased neuron number / MGI
- increased white fat cell number / MGI
- increased inguinal fat pad weight / MGI
- increased parametrial fat pad weight / MGI
- increased histiocytic sarcoma incidence / MGI
- abnormal prostate gland dorsolateral lobe morphology / MGI
- increased Leydig cell tumor incidence / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- increased sensitivity to xenobiotic induced morbidity/mortality / MGI
- decreased lymphoma incidence / MGI
- increased urinary system tumor incidence / MGI
- increased skin tumor incidence / MGI
- abnormal hematopoietic stem cell physiology / MGI
- increased fibroblast proliferation / MGI
- increased sebaceous gland adenoma incidence / MGI
- abnormal junctional epithelium morphology / MGI