B6.129S2-Evx2/Hoxd13tm4(cre)Ddu Del(2Hoxd11-Hoxd13)27Ddu/Orl

Status

Available to order

EMMA IDEM:01220
Citation informationRRID:IMSR_EM:01220 

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International strain nameB6.129S2-Evx2/Hoxd13tm4(cre)Ddu Del(2Hoxd11-Hoxd13)27Ddu/Orl
Alternative nameP1Del
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolEvx2/Hoxd13tm4(cre)Ddu, Del(2Hoxd11-Hoxd13)27Ddu
Gene/Transgene symbolHoxd13, Del(2Hoxd11-Hoxd13)27Ddu

Information from provider

ProviderDuboule Denis
Provider affiliationLaboratoire Moléculaire et Morphogenèse
Genetic informationInsertion of the Hoxd11Cre transgene between Evx2 and Hoxd13 and deletion of Hoxd13 to Hoxd11 genes by TArgeted MEiotic REcombination (TAMERE).
Phenotypic informationNone.
Breeding historyBackcross: N=10; Intercross: N=10.
References
  • A nested deletion approach to generate Cre deleter mice with progressive Hox profiles.;Hérault Yann, Kmita Marie, Sawaya Chadi C, Duboule Denis, ;2002;The International journal of developmental biology;46;185-91; 11902682

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • delayed bone ossification / MGI
  • rectal prolapse / MGI
  • abnormal forelimb morphology / MGI
  • abnormal carpal bone morphology / MGI
  • absent carpal bone / MGI
  • polydactyly / MGI
  • syndactyly / MGI
  • interdigital webbing / MGI
  • abnormal autopod morphology / MGI
  • abnormal smooth muscle morphology / MGI
  • decreased body weight / MGI
  • reduced male fertility / MGI
  • male infertility / MGI
  • abnormal seminal vesicle morphology / MGI
  • abnormal embryonic tissue morphology / MGI
  • abnormal digit morphology / MGI
  • brachyphalangia / MGI
  • brachydactyly / MGI
  • abnormal metatarsal bone morphology / MGI
  • abnormal metacarpal bone morphology / MGI
  • delayed endochondral bone ossification / MGI
  • polysyndactyly / MGI
  • short radius / MGI
  • short ulna / MGI
  • bowed ulna / MGI
  • bowed radius / MGI
  • sacral vertebral fusion / MGI
  • short metacarpal bones / MGI
  • short metatarsal bones / MGI
  • decreased metacarpal bone number / MGI
  • decreased metatarsal bone number / MGI
  • abnormal anus morphology / MGI
  • abnormal tarsal bone morphology / MGI
  • ectrodactyly / MGI
  • abnormal phalanx morphology / MGI
  • limbs/digits/tail phenotype / MGI
  • endocrine/exocrine gland phenotype / MGI
  • abnormal limb development / MGI
  • abnormal digit development / MGI
  • absent male preputial gland / MGI
  • abnormal bone ossification / MGI
  • abnormal hallux morphology / MGI
  • abnormal internal anal sphincter morphology / MGI
  • postaxial polydactyly / MGI
  • absent female preputial gland / MGI

Literature references

  • A nested deletion approach to generate Cre deleter mice with progressive Hox profiles.;Hérault Yann, Kmita Marie, Sawaya Chadi C, Duboule Denis, ;2002;The International journal of developmental biology;46;185-91; 11902682

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
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Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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