IMPC phenotypes (gene matching)
129S2/SvPas-Ins1tm1Jja/Orl
| Status | Available to order |
| EMMA ID | EM:01219 |
| International strain name | 129S2/SvPas-Ins1tm1Jja/Orl |
| Alternative name | Ins/1_129 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Ins1tm1Jja |
| Gene/Transgene symbol | Ins1 |
Information from provider
| Provider | Jacques Jami |
| Provider affiliation | Endocrinologie pédiatrique, INSERM U561, Groupe Hospitalier Cochin - Saint Vincent de Paul, Institut Cochin |
| Genetic information | Ins/1_129 mice carry a knock-out mutation of the gene coding for mouse proinsulin 1 (Ins1, or insulin I). These mice do not express any particular marker in the cells expressing the targeted gene. |
| Phenotypic information | These mice display no obvious phenotype, since the other proinsulin isoform compensate for the deficiency of the knocked-out isoform. |
| References |
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Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
Literature references
- Phenotypic alterations in insulin-deficient mutant mice.;Duvillié B, Cordonnier N, Deltour L, Dandoy-Dron F, Itier J M, Monthioux E, Jami J, Joshi R L, Bucchini D, ;1997;Proceedings of the National Academy of Sciences of the United States of America;94;5137-40; 9144203