IMPC phenotypes (gene matching)
129S2/SvPas-Ins1tm1Jja/Orl
| Status | Available to order |
| EMMA ID | EM:01219 |
| Citation information | RRID:IMSR_EM:01219 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | 129S2/SvPas-Ins1tm1Jja/Orl |
| Alternative name | Ins/1_129 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Ins1tm1Jja |
| Gene/Transgene symbol | Ins1 |
Information from provider
| Provider | Jacques Jami |
| Provider affiliation | Endocrinologie pédiatrique, INSERM U561, Groupe Hospitalier Cochin - Saint Vincent de Paul, Institut Cochin |
| Genetic information | Ins/1_129 mice carry a knock-out mutation of the gene coding for mouse proinsulin 1 (Ins1, or insulin I). These mice do not express any particular marker in the cells expressing the targeted gene. |
| Phenotypic information | These mice display no obvious phenotype, since the other proinsulin isoform compensate for the deficiency of the knocked-out isoform. |
| References |
|
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
Literature references
- Phenotypic alterations in insulin-deficient mutant mice.;Duvillié B, Cordonnier N, Deltour L, Dandoy-Dron F, Itier J M, Monthioux E, Jami J, Joshi R L, Bucchini D, ;1997;Proceedings of the National Academy of Sciences of the United States of America;94;5137-40; 9144203