MGI phenotypes (allele matching)
129S2/SvPas-Ins2tm1Jja/Orl
| Status | Available to order |
| EMMA ID | EM:01218 |
| International strain name | 129S2/SvPas-Ins2tm1Jja/Orl |
| Alternative name | Ins/2_LacZ_129 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Ins2tm1Jja |
| Gene/Transgene symbol | Ins2 |
Information from provider
| Provider | Jacques Jami |
| Provider affiliation | Endocrinologie pédiatrique, INSERM U561, Groupe Hospitalier Cochin - Saint Vincent de Paul, Institut Cochin |
| Genetic information | These mice carry a knock-out mutation of the gene coding for mouse proinsulin-2 (Ins2, or insulin II) and express LacZ in their islets. This property can be used for tracking proinsulin-2 expressing cells in the islets or thymus (see Chentoufi et al Diabetes 2004). |
| Phenotypic information | Deficiency of proinsulin expression by thymic epithelial cells |
| References |
|
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
MGI allele-associated human disease models
MGI phenotypes (gene matching)
- decreased bone mineral density / MGI
- abnormal microglial cell morphology / MGI
- kyphosis / MGI
- increased leukocyte cell number / MGI
- hydronephrosis / MGI
- decreased body weight / MGI
- increased anxiety-related response / MGI
- hypoactivity / MGI
- polydipsia / MGI
- dehydration / MGI
- polyphagia / MGI
- hyperglycemia / MGI
- postnatal growth retardation / MGI
- increased urine glucose level / MGI
- polyuria / MGI
- abnormal glucose homeostasis / MGI
- postnatal lethality / MGI
- premature death / MGI
- no abnormal phenotype detected / MGI
- abnormal astrocyte morphology / MGI
- increased circulating ketone body level / MGI
- hepatic steatosis / MGI
- akinesia / MGI
- abnormal pancreas physiology / MGI
- decreased circulating insulin level / MGI
- abnormal Leydig cell morphology / MGI
- abnormal retinal vasculature morphology / MGI
- increased anti-insulin autoantibody level / MGI
- albuminuria / MGI
- increased insulin sensitivity / MGI
- no phenotypic analysis / MGI
- increased insulin secretion / MGI
- decreased insulin secretion / MGI
- increased vascular permeability / MGI
- decreased pancreatic beta cell number / MGI
- abnormal pancreatic beta cell physiology / MGI
- increased pancreatic beta cell number / MGI
- insulitis / MGI
- increased susceptibility to autoimmune diabetes / MGI
- abnormal pancreatic islet morphology / MGI
- abnormal pancreatic alpha cell morphology / MGI
- abnormal pancreatic beta cell morphology / MGI
- abnormal retinal ganglion layer morphology / MGI
- glomerulosclerosis / MGI
- impaired glucose tolerance / MGI
- insulin resistance / MGI
- homeostasis/metabolism phenotype / MGI
- increased renal glomerular filtration rate / MGI
- increased circulating glucose level / MGI
- decreased circulating leptin level / MGI
- abnormal response to transplant / MGI
- abnormal mitochondrion morphology / MGI
- abnormal retinal neuronal layer morphology / MGI
- hematoma / MGI
- decreased subcutaneous adipose tissue amount / MGI
- increased pancreatic beta cell mass / MGI
- decreased pancreatic beta cell mass / MGI
- small pancreatic islets / MGI
- absent pancreatic beta cells / MGI
- increased pancreatic alpha cell number / MGI
- decreased pancreatic alpha cell number / MGI
- disorganized pancreatic islets / MGI
- degranulated pancreatic beta cells / MGI
- postnatal lethality, complete penetrance / MGI
- abnormal glomerular capillary morphology / MGI
- expanded mesangial matrix / MGI
- increased renal glomerulus basement membrane thickness / MGI
- abnormal kidney interstitium morphology / MGI
- increased food intake / MGI
- increased fluid intake / MGI
- increased pancreatic islet cell apoptosis / MGI
- renal glomerular protein deposits / MGI
- increased retinal apoptosis / MGI
Literature references
- Phenotypic alterations in insulin-deficient mutant mice.;Duvillié B, Cordonnier N, Deltour L, Dandoy-Dron F, Itier J M, Monthioux E, Jami J, Joshi R L, Bucchini D, ;1997;Proceedings of the National Academy of Sciences of the United States of America;94;5137-40; 9144203