MGI phenotypes (allele matching)
129S2/SvPas-Ins2tm1Jja/Orl
| Status | Available to order |
| EMMA ID | EM:01218 |
| Citation information | RRID:IMSR_EM:01218 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | 129S2/SvPas-Ins2tm1Jja/Orl |
| Alternative name | Ins/2_LacZ_129 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Ins2tm1Jja |
| Gene/Transgene symbol | Ins2 |
Information from provider
| Provider | Jacques Jami |
| Provider affiliation | Endocrinologie pédiatrique, INSERM U561, Groupe Hospitalier Cochin - Saint Vincent de Paul, Institut Cochin |
| Genetic information | These mice carry a knock-out mutation of the gene coding for mouse proinsulin-2 (Ins2, or insulin II) and express LacZ in their islets. This property can be used for tracking proinsulin-2 expressing cells in the islets or thymus (see Chentoufi et al Diabetes 2004). |
| Phenotypic information | Deficiency of proinsulin expression by thymic epithelial cells |
| References |
|
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
MGI allele-associated human disease models
MGI phenotypes (gene matching)
- decreased bone mineral density / MGI
- abnormal microglial cell morphology / MGI
- kyphosis / MGI
- increased leukocyte cell number / MGI
- hydronephrosis / MGI
- decreased body weight / MGI
- increased anxiety-related response / MGI
- hypoactivity / MGI
- polydipsia / MGI
- dehydration / MGI
- polyphagia / MGI
- hyperglycemia / MGI
- postnatal growth retardation / MGI
- increased urine glucose level / MGI
- polyuria / MGI
- abnormal glucose homeostasis / MGI
- postnatal lethality / MGI
- premature death / MGI
- no abnormal phenotype detected / MGI
- abnormal astrocyte morphology / MGI
- increased circulating ketone body level / MGI
- hepatic steatosis / MGI
- akinesia / MGI
- abnormal pancreas physiology / MGI
- decreased circulating insulin level / MGI
- abnormal Leydig cell morphology / MGI
- abnormal retinal vasculature morphology / MGI
- increased anti-insulin autoantibody level / MGI
- albuminuria / MGI
- increased insulin sensitivity / MGI
- no phenotypic analysis / MGI
- increased insulin secretion / MGI
- decreased insulin secretion / MGI
- increased vascular permeability / MGI
- decreased pancreatic beta cell number / MGI
- abnormal pancreatic beta cell physiology / MGI
- increased pancreatic beta cell number / MGI
- insulitis / MGI
- increased susceptibility to autoimmune diabetes / MGI
- abnormal pancreatic islet morphology / MGI
- abnormal pancreatic alpha cell morphology / MGI
- abnormal pancreatic beta cell morphology / MGI
- abnormal retinal ganglion layer morphology / MGI
- glomerulosclerosis / MGI
- impaired glucose tolerance / MGI
- insulin resistance / MGI
- homeostasis/metabolism phenotype / MGI
- increased renal glomerular filtration rate / MGI
- increased circulating glucose level / MGI
- decreased circulating leptin level / MGI
- abnormal response to transplant / MGI
- abnormal mitochondrion morphology / MGI
- abnormal retinal neuronal layer morphology / MGI
- hematoma / MGI
- decreased subcutaneous adipose tissue amount / MGI
- increased pancreatic beta cell mass / MGI
- decreased pancreatic beta cell mass / MGI
- small pancreatic islets / MGI
- absent pancreatic beta cells / MGI
- increased pancreatic alpha cell number / MGI
- decreased pancreatic alpha cell number / MGI
- disorganized pancreatic islets / MGI
- degranulated pancreatic beta cells / MGI
- postnatal lethality, complete penetrance / MGI
- abnormal glomerular capillary morphology / MGI
- expanded mesangial matrix / MGI
- increased renal glomerulus basement membrane thickness / MGI
- abnormal kidney interstitium morphology / MGI
- increased food intake / MGI
- increased fluid intake / MGI
- increased pancreatic islet cell apoptosis / MGI
- renal glomerular protein deposits / MGI
- increased retinal apoptosis / MGI
Literature references
- Phenotypic alterations in insulin-deficient mutant mice.;Duvillié B, Cordonnier N, Deltour L, Dandoy-Dron F, Itier J M, Monthioux E, Jami J, Joshi R L, Bucchini D, ;1997;Proceedings of the National Academy of Sciences of the United States of America;94;5137-40; 9144203