C57BL/6NCrl-Klk8em1(IMPC)Ccpcz/Ph

Status

Available to order

EMMA IDEM:12177
International strain nameC57BL/6NCrl-Klk8em1(IMPC)Ccpcz/Ph
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolKlk8em1(IMPC)Ccpcz
Gene/Transgene symbolKlk8

Information from provider

Provider Institute of Molecular Genetics
Provider affiliationDepartment of Transgenic Models of Diseases, Institute of Molecular Genetics
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitute of Molecular Genetics, Prague, Czech Republic
Animals used for archivingheterozygous C57BL/6NCrl

Disease and phenotype information

IMPC phenotypes (allele matching)
  • abnormal spleen morphology / IMPC
  • enlarged spleen / IMPC
  • abnormal kidney morphology / IMPC
  • decreased lymphocyte cell number / IMPC
IMPC phenotypes (gene matching)
  • abnormal spleen morphology / IMPC
  • abnormal kidney morphology / IMPC
  • enlarged spleen / IMPC
  • decreased lymphocyte cell number / IMPC
MGI phenotypes (gene matching)
  • abnormal hippocampus morphology / MGI
  • increased susceptibility to pharmacologically induced seizures / MGI
  • abnormal excitatory postsynaptic potential / MGI
  • abnormal GABAergic neuron morphology / MGI
  • nervous system phenotype / MGI
  • abnormal brain interneuron morphology / MGI
  • decreased CNS synapse formation / MGI
  • behavior/neurological phenotype / MGI
  • abnormal hippocampus pyramidal cell layer / MGI
  • abnormal synaptic bouton morphology / MGI
  • increased sensitivity to xenobiotic induced morbidity/mortality / MGI
  • abnormal hippocampus pyramidal cell morphology / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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