B6Brd;B6N-Tyrc-Brd Kmt5btm1a(KOMP)Wtsi/Wtsi

Status

Available to order

EMMA IDEM:12138
International strain nameB6Brd;B6N-Tyrc-Brd Kmt5btm1a(KOMP)Wtsi/Wtsi
Alternative nameEPD0022_2_D02
Strain typeTargeted Mutant Strains
Allele/Transgene symbolKmt5btm1a(KOMP)Wtsi
Gene/Transgene symbolKmt5b
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from KOMP ES clone EPD0022_2_D02. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreWellcome Trust Sanger Institute, Hinxton, United Kingdom
Animals used for archivingheterozygous C57BL/6Dnk;C57BL/6Brd-Tyr;C57BL/6N

Disease and phenotype information

IMPC phenotypes (allele matching)
  • decreased body length / IMPC
  • decreased body weight / IMPC
  • abnormal tail movements / IMPC
  • increased thermal nociceptive threshold / IMPC
  • increased circulating chloride level / IMPC
  • decreased total body fat amount / IMPC
  • decreased bone mineral content / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
  • process of degenerative change / IMPC
  • lipid deposition / IMPC
IMPC phenotypes (gene matching)
  • decreased body weight / IMPC
  • decreased bone mineral content / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
  • decreased body length / IMPC
  • process of degenerative change / IMPC
  • abnormal tail movements / IMPC
  • lipid deposition / IMPC
  • increased thermal nociceptive threshold / IMPC
  • decreased total body fat amount / IMPC
  • increased circulating chloride level / IMPC
MGI phenotypes (gene matching)
  • decreased body length / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • increased thermal nociceptive threshold / MGI
  • abnormal pulmonary alveolus morphology / MGI
  • decreased circulating alanine transaminase level / MGI
  • decreased lumbar vertebrae number / MGI
  • decreased total body fat amount / MGI
  • increased sacral vertebrae number / MGI
  • neonatal lethality, complete penetrance / MGI
  • prenatal lethality, incomplete penetrance / MGI

Information on how we integrate external resources can be found here

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

    Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

    * In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

    More details on pricing and delivery times

    Practical information

    Example health report
    (Current health report will be provided later)

    Material Transfer Agreement (MTA)
    Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

    EMMA conditions
    Legally binding conditions for the transfer

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