B6Brd;B6N-Tyrc-Brd Selenontm1a(KOMP)Wtsi/Wtsi

Status

Available to order

EMMA IDEM:12121
International strain nameB6Brd;B6N-Tyrc-Brd Selenontm1a(KOMP)Wtsi/Wtsi
Alternative nameEPD0132_5_C11
Strain typeTargeted Mutant Strains
Allele/Transgene symbolSelenontm1a(KOMP)Wtsi
Gene/Transgene symbolSelenon
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from KOMP ES clone EPD0132_5_C11. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
References
  • Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.;White Jacqueline K, Gerdin Anna-Karin, Karp Natasha A, Ryder Ed, Buljan Marija, Bussell James N, Salisbury Jennifer, Clare Simon, Ingham Neil J, Podrini Christine, Houghton Richard, Estabel Jeanne, Bottomley Joanna R, Melvin David G, Sunter David, Adams Niels C, null null, Tannahill David, Logan Darren W, Macarthur Daniel G, Flint Jonathan, Mahajan Vinit B, Tsang Stephen H, Smyth Ian, Watt Fiona M, Skarnes William C, Dougan Gordon, Adams David J, Ramirez-Solis Ramiro, Bradley Allan, Steel Karen P, ;2013;Cell;154;452-64; 23870131

Information from EMMA

Archiving centreWellcome Trust Sanger Institute, Hinxton, United Kingdom
Animals used for archivingheterozygous C57BL/6Dnk;C57BL/6Brd-Tyr;C57BL/6N

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (allele matching)
  • vertebral fusion / IMPC
  • process of degenerative change / IMPC
  • hydrocephalus / IMPC
IMPC phenotypes (gene matching)
  • hydrocephalus / IMPC
  • process of degenerative change / IMPC
  • vertebral fusion / IMPC
MGI phenotypes (gene matching)
  • kyphosis / MGI
  • abnormal muscle regeneration / MGI
  • abnormal skeletal muscle morphology / MGI
  • abnormal lung development / MGI
  • hypoactivity / MGI
  • abnormal lung volume / MGI
  • abnormal muscle physiology / MGI
  • abnormal respiratory system physiology / MGI
  • decreased vertical activity / MGI
  • decreased satellite cell number / MGI
  • vertebral fusion / MGI
  • decreased skeletal muscle mass / MGI
  • increased apoptosis / MGI
  • decreased skeletal muscle fiber size / MGI
  • decreased skeletal muscle fiber diameter / MGI
  • centrally nucleated skeletal muscle fibers / MGI
  • abnormal skeletal muscle fiber type ratio / MGI
  • skeletal muscle atrophy / MGI
  • decreased gastrocnemius weight / MGI
  • decreased extensor digitorum longus weight / MGI
  • decreased soleus weight / MGI
  • decreased tibialis anterior weight / MGI
  • skeletal muscle hypertrophy / MGI
  • decreased susceptibility to weight gain / MGI
  • decreased quadriceps weight / MGI
  • increased lung compliance / MGI
  • abnormal pulmonary alveolar sac morphology / MGI
  • decreased lung elastance / MGI
  • enhanced exercise endurance / MGI

Literature references

  • Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.;White Jacqueline K, Gerdin Anna-Karin, Karp Natasha A, Ryder Ed, Buljan Marija, Bussell James N, Salisbury Jennifer, Clare Simon, Ingham Neil J, Podrini Christine, Houghton Richard, Estabel Jeanne, Bottomley Joanna R, Melvin David G, Sunter David, Adams Niels C, null null, Tannahill David, Logan Darren W, Macarthur Daniel G, Flint Jonathan, Mahajan Vinit B, Tsang Stephen H, Smyth Ian, Watt Fiona M, Skarnes William C, Dougan Gordon, Adams David J, Ramirez-Solis Ramiro, Bradley Allan, Steel Karen P, ;2013;Cell;154;452-64; 23870131

Information on how we integrate external resources can be found here

Register interest

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

    Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

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    More details on pricing and delivery times

    Practical information

    Example health report
    (Current health report will be provided later)

    Material Transfer Agreement (MTA)
    Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

    EMMA conditions
    Legally binding conditions for the transfer

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