IMPC phenotypes (gene matching)
B6;Cg-Nrp1tm1.1Cruh/H
| Status | Available to order |
| EMMA ID | EM:11987 |
| International strain name | B6;Cg-Nrp1tm1.1Cruh/H |
| Alternative name | Nrp1cyto |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Nrp1tm1.1Cruh |
| Gene/Transgene symbol | Nrp1 |
Information from provider
| Provider | Christiana Ruhrberg |
| Provider affiliation | UCL Institute of Ophthalmology, University College London |
| Genetic information | A 4 base-pair insertion (AATT) into the Nrp1 last exon after the transmembrane domain coding sequence, shifting the reading frame and preventing translation of the cytoplasmic domain of Nrp1. |
| Phenotypic information | Homozygous:The analysis of pre- and perinatal vascular development revealed that vasculogenesis and angiogenesis proceed normally in these mutants, demonstrating that the Nrp1 membrane-anchored extracellular domain is sufficient for vessel growth. By contrast, the cytoplasmic domain is required for normal arteriovenous patterning, because arteries and veins crossed each other at an abnormally high frequency in the Nrp1-cyto delta/delta retina. At crossing sites, the artery was positioned anteriorly to the vein, and both vessels were embedded in a shared collagen sleeve.Heterozygous:-- |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI allele-associated human disease models
MGI phenotypes (gene matching)
- abnormal vascular development / MGI
- abnormal pulmonary artery morphology / MGI
- abnormal corpus callosum morphology / MGI
- abnormal hippocampus morphology / MGI
- abnormal facial motor nucleus morphology / MGI
- abnormal dorsal root ganglion morphology / MGI
- abnormal cranial nerve morphology / MGI
- abnormal trigeminal nerve morphology / MGI
- abnormal facial nerve morphology / MGI
- abnormal vestibulocochlear nerve morphology / MGI
- abnormal spinal nerve morphology / MGI
- decreased body size / MGI
- disorganized yolk sac vascular plexus / MGI
- postnatal growth retardation / MGI
- postnatal lethality / MGI
- premature death / MGI
- abnormal dendritic cell physiology / MGI
- abnormal T cell physiology / MGI
- persistent truncus arteriosis / MGI
- abnormal pharyngeal arch artery morphology / MGI
- abnormal retinal vasculature morphology / MGI
- abnormal axon guidance / MGI
- dilated heart atrium / MGI
- decreased tumor growth/size / MGI
- nervous system phenotype / MGI
- vascular smooth muscle hypoplasia / MGI
- transposition of great arteries / MGI
- abnormal coronary artery morphology / MGI
- right aortic arch / MGI
- double aortic arch / MGI
- abnormal dorsal aorta morphology / MGI
- abnormal brain vasculature morphology / MGI
- cardiovascular system phenotype / MGI
- vision/eye phenotype / MGI
- decreased angiogenesis / MGI
- abnormal neuronal migration / MGI
- abnormal fourth pharyngeal arch artery morphology / MGI
- abnormal sixth pharyngeal arch artery morphology / MGI
- abnormal third pharyngeal arch artery morphology / MGI
- abnormal induced retinal neovascularization / MGI
- abnormal retinal blood vessel morphology / MGI
- abnormal retinal blood vessel pattern / MGI
- abnormal first pharyngeal arch artery morphology / MGI
- abnormal second pharyngeal arch artery morphology / MGI
- abnormal aortic arch and aortic arch branch attachment / MGI
- abnormal coronary vessel morphology / MGI
- postnatal lethality, incomplete penetrance / MGI
- embryonic lethality, complete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
Literature references
- The cytoplasmic domain of neuropilin 1 is dispensable for angiogenesis, but promotes the spatial separation of retinal arteries and veins.;Fantin Alessandro, Schwarz Quenten, Davidson Kathryn, Normando Eduardo M, Denti Laura, Ruhrberg Christiana, ;2011;Development (Cambridge, England);138;4185-91; 21852397