IMPC phenotypes (gene matching)
FVB-Il31raem2Phep/Cnrm
| Status | Available to order |
| EMMA ID | EM:11961 |
| Citation information | RRID:IMSR_EM:11961 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | FVB-Il31raem2Phep/Cnrm |
| Alternative name | Il31raS476F |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Il31raem2Phep |
| Gene/Transgene symbol | Il31ra |
Information from provider
| Provider | Paul Heppenstall |
| Provider affiliation | European Molecular Biology Laboratory |
| Genetic information | This mouse strain was generated using CRISPR/Cas9-mediated genome editing to knock-in a point mutation within exon 14 of the locus Il31ra (TCT>TTT) resulting in an aminoacid substitution in position 476 of a serine with a phenylalanine. |
| Phenotypic information | Homozygous:Homozygous mice show spontaneous fur loss, sometimes with severe skin lesions all over the body, amyloid deposits in the skin (detectable with specific staining) and itchy skin.Heterozygous:Heterozygous mice show spontaneous fur loss, sometimes with severe skin lesions all over the body, amyloid deposits in the skin (detectable with specific staining) and itchy skin. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | not known |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Familial primary localized cutaneous amyloidosis / Orphanet_353220
MGI phenotypes (gene matching)
- decreased bone marrow cell number / MGI
- spleen hypoplasia / MGI
- abnormal bone marrow cell morphology/development / MGI
- abnormal macrophage physiology / MGI
- increased IgE level / MGI
- granulomatous inflammation / MGI
- increased susceptibility to parasitic infection / MGI
- increased T cell proliferation / MGI
- immune system phenotype / MGI
- abnormal common myeloid progenitor cell morphology / MGI
- abnormal interleukin level / MGI
Literature references
- Interleukin-31-mediated photoablation of pruritogenic epidermal neurons reduces itch-associated behaviours in mice.;Nocchi Linda, Roy Nainika, D'Attilia Mariangela, Dhandapani Rahul, Maffei Mariano, Traista Andrei, Castaldi Laura, Perlas Emerald, Chadick Cora Hallie, Heppenstall Paul A, ;2019;Nature biomedical engineering;3;114-125; 30944432