IMPC phenotypes (gene matching)
FVB-Il31raem1Phep/Cnrm
| Status | Available to order |
| EMMA ID | EM:11960 |
| Citation information | RRID:IMSR_EM:11960 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | FVB-Il31raem1Phep/Cnrm |
| Alternative name | Il31ra 8bp deletion KO |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Il31raem1Phep |
| Gene/Transgene symbol | Il31ra |
Information from provider
| Provider | Paul Heppenstall |
| Provider affiliation | European Molecular Biology Laboratory |
| Genetic information | This mouse line was generated by CRISPR/Cas9-mediated genome editing, which knocked out the Il31ra gene by a 8 bp deletion into the exon 14 of the Il31ra locus. |
| Phenotypic information | Homozygous:Homozygous mice show a normal phenotype, are healthy and fertile.Heterozygous:Heterozygous mice show a normal phenotype, are healthy and fertile. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | yes |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Familial primary localized cutaneous amyloidosis / Orphanet_353220
MGI phenotypes (gene matching)
- decreased bone marrow cell number / MGI
- spleen hypoplasia / MGI
- abnormal bone marrow cell morphology/development / MGI
- abnormal macrophage physiology / MGI
- increased IgE level / MGI
- granulomatous inflammation / MGI
- increased susceptibility to parasitic infection / MGI
- increased T cell proliferation / MGI
- immune system phenotype / MGI
- abnormal common myeloid progenitor cell morphology / MGI
- abnormal interleukin level / MGI
Literature references
- Interleukin-31-mediated photoablation of pruritogenic epidermal neurons reduces itch-associated behaviours in mice.;Nocchi Linda, Roy Nainika, D'Attilia Mariangela, Dhandapani Rahul, Maffei Mariano, Traista Andrei, Castaldi Laura, Perlas Emerald, Chadick Cora Hallie, Heppenstall Paul A, ;2019;Nature biomedical engineering;3;114-125; 30944432
- Molecule guided laser ablation as a novel therapeutic strategy to control itch;Nocchi L, D’Attilia M, Roy N, Dhandapani R, Traista A, Maffei M, Castaldi L, Perlas E, Heppenstall PA;2018;Biorxiv unrefereed preprint full text;;;