FVB-Il31raem1Phep/Cnrm
Status | Available to order |
EMMA ID | EM:11960 |
International strain name | FVB-Il31raem1Phep/Cnrm |
Alternative name | Il31ra 8bp deletion KO |
Strain type | Endonuclease-mediated |
Allele/Transgene symbol | Il31raem1Phep |
Gene/Transgene symbol | Il31ra |
Information from provider
Provider | Paul Heppenstall |
Provider affiliation | European Molecular Biology Laboratory |
Genetic information | This mouse line was generated by CRISPR/Cas9-mediated genome editing, which knocked out the Il31ra gene by a 8 bp deletion into the exon 14 of the Il31ra locus. |
Phenotypic information | Homozygous:Homozygous mice show a normal phenotype, are healthy and fertile.Heterozygous:Heterozygous mice show a normal phenotype, are healthy and fertile. |
References |
|
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | yes |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Familial primary localized cutaneous amyloidosis / Orphanet_353220
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- decreased bone marrow cell number / MGI
- spleen hypoplasia / MGI
- abnormal bone marrow cell morphology/development / MGI
- abnormal macrophage physiology / MGI
- increased IgE level / MGI
- granulomatous inflammation / MGI
- increased susceptibility to parasitic infection / MGI
- increased T cell proliferation / MGI
- immune system phenotype / MGI
- abnormal common myeloid progenitor cell morphology / MGI
- abnormal interleukin level / MGI
Literature references
- Interleukin-31-mediated photoablation of pruritogenic epidermal neurons reduces itch-associated behaviours in mice.;Nocchi Linda, Roy Nainika, D'Attilia Mariangela, Dhandapani Rahul, Maffei Mariano, Traista Andrei, Castaldi Laura, Perlas Emerald, Chadick Cora Hallie, Heppenstall Paul A, ;2019;Nature biomedical engineering;3;114-125; 30944432
- Molecule guided laser ablation as a novel therapeutic strategy to control itch;Nocchi L, D’Attilia M, Roy N, Dhandapani R, Traista A, Maffei M, Castaldi L, Perlas E, Heppenstall PA;2018;Biorxiv unrefereed preprint full text;;;
Information on how we integrate external resources can be found here
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).