B6(Cg)-Tg(Th-rtTA)4Ekra/EkraH

Status

Available to order

EMMA IDEM:11951
International strain nameB6(Cg)-Tg(Th-rtTA)4Ekra/EkraH
Alternative nameC57BL/6J-Tg(TH-rtTA3G)4EKra
Strain typeTransgenic Strains
Allele/Transgene symbolUnknown at present
Gene/Transgene symbolmTH-rtTA3G

Information from provider

ProviderEdgar Kramer
Provider affiliationBiomedical Research, Institute of Translational and Stratified Medicine, Peninsula Schools of Medicine and Dentistry, University of Plymouth
Genetic informationrtTA3G under the control of the mouse Th promoter (8.9kbp).
Phenotypic informationHomozygous:
Not generated.

Heterozygous:
mTH-rtTA ON#3205 can be used to induce rtTA expression in catecholaminergic neurons expressing tyrosine hydroxylase; rtTA can induce gene expression in the presence of tetracycline/doxycycline (Tillack et al., 2015). No obvious phenotype has been observed in the heterozygous mice.
Breeding historyIntercrosses with C57BL/6 x BALB/c F2-Tg(tetO-cre)LC1Bjd mouse line.
References
  • An Efficient and Versatile System for Visualization and Genetic Modification of Dopaminergic Neurons in Transgenic Mice.;Tillack Karsten, Aboutalebi Helia, Kramer Edgar R, ;2015;PloS one;10;e0136203; 26291828
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Literature references

  • An Efficient and Versatile System for Visualization and Genetic Modification of Dopaminergic Neurons in Transgenic Mice.;Tillack Karsten, Aboutalebi Helia, Kramer Edgar R, ;2015;PloS one;10;e0136203; 26291828

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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