IMPC phenotypes (gene matching)
B6.129P2-Mr1tm1Gfn/Orl
| Status | Available to order |
| EMMA ID | EM:11942 |
| International strain name | B6.129P2-Mr1tm1Gfn/Orl |
| Alternative name | MR1 Knock Out |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Mr1tm1Gfn |
| Gene/Transgene symbol | Mr1 |
Information from provider
| Provider | Seiamak Bahram |
| Provider affiliation | IRM, U1109 |
| Genetic information | Targeted Knock out mice for MHC class I chain related gene (MR1) |
| Phenotypic information | Homozygous:Defect in the control of infection by Klesbiella pneumoniae in mice. Significantly increased susceptibility to Salmonella typhimurium in MR1 KO animals. A number of key cytokines is reduced in MR1 KO mice: - very low expression of TNF-alpha - strong reduction of IL17 expression. Perturbation in the balance between pro- and anti-inflammatory molecules in infected MR1 mutants compared to controls: - reduction of IL1beta expression - MIP-1alpha strongly inhibited in infected mutant mice Heterozygous:No phenotype |
| Breeding history | congenic-inbred mice |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | homozygous C57BL/6J |
Disease and phenotype information
Literature references
- The non-conventional MHC class I MR1 molecule controls infection by Klebsiella pneumoniae in mice.;Georgel Philippe, Radosavljevic Mirjana, Macquin Cécile, Bahram Seiamak, ;2011;Molecular immunology;48;769-75; 21190736