IMPC phenotypes (gene matching)
B6.129P2-Mr1tm1Gfn/Orl
| Status | Available to order |
| EMMA ID | EM:11942 |
| Citation information | RRID:IMSR_EM:11942 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129P2-Mr1tm1Gfn/Orl |
| Alternative name | MR1 Knock Out |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Mr1tm1Gfn |
| Gene/Transgene symbol | Mr1 |
Information from provider
| Provider | Seiamak Bahram |
| Provider affiliation | IRM, U1109 |
| Genetic information | Targeted Knock out mice for MHC class I chain related gene (MR1) |
| Phenotypic information | Homozygous:Defect in the control of infection by Klesbiella pneumoniae in mice. Significantly increased susceptibility to Salmonella typhimurium in MR1 KO animals. A number of key cytokines is reduced in MR1 KO mice: - very low expression of TNF-alpha - strong reduction of IL17 expression. Perturbation in the balance between pro- and anti-inflammatory molecules in infected MR1 mutants compared to controls: - reduction of IL1beta expression - MIP-1alpha strongly inhibited in infected mutant mice Heterozygous:No phenotype |
| Breeding history | congenic-inbred mice |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | homozygous C57BL/6J males |
Disease and phenotype information
Literature references
- The non-conventional MHC class I MR1 molecule controls infection by Klebsiella pneumoniae in mice.;Georgel Philippe, Radosavljevic Mirjana, Macquin Cécile, Bahram Seiamak, ;2011;Molecular immunology;48;769-75; 21190736