IMPC phenotypes (allele matching)
- preweaning lethality, complete penetrance / IMPC
C57BL/6NCrl-Hgstm1b(EUCOMM)Wtsi/Ieg
| Status | Available to order |
| EMMA ID | EM:11940 |
| International strain name | C57BL/6NCrl-Hgstm1b(EUCOMM)Wtsi/Ieg |
| Alternative name | EPD0060_1_B12 |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Hgstm1b(EUCOMM)Wtsi |
| Gene/Transgene symbol | Hgs |
| Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
| Provider | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH) |
| Provider affiliation | Institute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH) |
| Genetic information | This mouse line originates from EUCOMM ES clone EPD0060_1_B12. For further details on the construction of this clone see the page at the IMPC portal. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele. Click here for more information on EUCOMM final vectors. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | heterozygous C57BL/6N |
Disease and phenotype information
MGI phenotypes (gene matching)
- paralysis / MGI
- abnormal medulla oblongata morphology / MGI
- small cerebellum / MGI
- Purkinje cell degeneration / MGI
- abnormal brain development / MGI
- open neural tube / MGI
- wavy neural tube / MGI
- abnormal CNS glial cell morphology / MGI
- decreased spinal cord size / MGI
- abnormal spinal nerve morphology / MGI
- decreased body height / MGI
- decreased body size / MGI
- abnormal stationary movement / MGI
- increased stereotypic behavior / MGI
- abnormal posture / MGI
- abnormal motor coordination/balance / MGI
- impaired swimming / MGI
- impaired balance / MGI
- abnormal somite development / MGI
- decreased embryo size / MGI
- postnatal growth retardation / MGI
- premature death / MGI
- abnormal embryonic tissue morphology / MGI
- abnormal extraembryonic tissue morphology / MGI
- muscular atrophy / MGI
- opisthotonus / MGI
- axonal dystrophy / MGI
- abnormal myelin sheath morphology / MGI
- abnormal cerebellar cortex morphology / MGI
- failure of initiation of embryo turning / MGI
- cardia bifida / MGI
- dilated allantois / MGI
- abnormal vertebral spinous process morphology / MGI
- abnormal vertebral column morphology / MGI
- short vertebral body / MGI
- cachexia / MGI
- bradykinesia / MGI
- abnormal rostral-caudal axis patterning / MGI
- hearing/vestibular/ear phenotype / MGI
- abnormal axon morphology / MGI
- jerky movement / MGI
- abnormal cell physiology / MGI
- thin cerebellar granule layer / MGI
- embryonic lethality between implantation and somite formation / MGI
- abnormal spinal cord white matter morphology / MGI
- abnormal spinal cord grey matter morphology / MGI
- decreased neuron number / MGI
- decreased trabecular bone thickness / MGI
- abnormal resting posture / MGI
- failure of chorioallantoic fusion / MGI
- embryonic lethality, complete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- absent foregut / MGI
- decreased midbrain size / MGI
- decreased hindbrain size / MGI
- decreased corticospinal tract size / MGI
- decreased pons size / MGI