- abnormal thymus morphology / IMPC
- abnormal vertebrae morphology / IMPC
- abnormal testis morphology / IMPC
- abnormal vertebral arch morphology / IMPC
- hydrometra / IMPC
- abnormal heart left ventricle morphology / IMPC
- enlarged thymus / IMPC
- small testis / IMPC
- abnormal heart morphology / IMPC
- enlarged heart / IMPC
- abnormal spleen morphology / IMPC
- small spleen / IMPC
- enlarged spleen / IMPC
- increased cardiac muscle contractility / IMPC
- kyphosis / IMPC
- abnormal retina morphology / IMPC
- abnormal spine curvature / IMPC
- abnormal uterus morphology / IMPC
B6.129-Calb1tm2.1Mpin/Biat
Status | Available to order |
EMMA ID | EM:11899 |
International strain name | B6.129-Calb1tm2.1Mpin/Biat |
Alternative name | B6.(R1)-Calb1 |
Strain type | Targeted Mutant Strains : Conditional mutation |
Allele/Transgene symbol | Calb1tm2.1Mpin |
Gene/Transgene symbol | Calb1 |
Information from provider
Provider | Michael Meyer |
Provider affiliation | Physiology, Biomedical Center LMU München |
Genetic information | The strain is a conditional inactivation of the Calb1 gene (see EM:09881, B6.129-Calb1tm1Mpin/JBiat). The targeting vector was obtained by inserting a single loxP site upstream and a floxed neo-TK cassette downstream of the first exon (Fig. 1a in PMID: 11857810 Barski et al. Genesis 2002). |
Phenotypic information | Homozygous:none (see PMID: 11857810 Barski et al. Genesis 2002)Heterozygous:none |
References |
|
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | University of Veterinary Medicine, Vienna, Austria |
Animals used for archiving | heterozygous C57BL/6N |
Disease and phenotype information
IMPC phenotypes (gene matching)
Literature references
- Conditional inactivation of the calbindin D-28k (Calb1) gene by Cre/loxP-mediated recombination.;Barski Jaroslaw J, Mörl Karin, Meyer Michael, ;2002;Genesis (New York, N.Y. : 2000);32;165-8; 11857810
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