C57BL/6NCrl-Hycc1^{em1(IMPC)Ccpcz}/Ph

Status	Available to order
EMMA ID	EM:11877
Citation information	RRID:IMSR_EM:11877 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57BL/6NCrl-Hycc1^{em1(IMPC)Ccpcz}/Ph
Alternative name
Strain type	Endonuclease-mediated
Allele/Transgene symbol	Hycc1^{em1(IMPC)Ccpcz}
Gene/Transgene symbol	Hycc1

Information from provider

Provider	Institute of Molecular Genetics
Provider affiliation	Department of Transgenic Models of Diseases, Institute of Molecular Genetics
Genetic information	This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	Institute of Molecular Genetics, Prague, Czech Republic
Animals used for archiving	heterozygous C57BL/6NCrl males

Disease and phenotype information

IMPC phenotypes (allele matching)

increased neutrophil cell number / IMPC
increased monocyte cell number / IMPC
abnormal salivary gland morphology / IMPC
small salivary gland / IMPC
enlarged thymus / IMPC
no spontaneous movement / IMPC
abnormal inspiratory capacity / IMPC
dilated heart left ventricle / IMPC
increased cardiac output / IMPC
increased circulating bilirubin level / IMPC
increased mean corpuscular hemoglobin / IMPC
decreased circulating total protein level / IMPC
increased circulating potassium level / IMPC
increased red blood cell distribution width / IMPC
increased lung compliance / IMPC
decreased lung elastance / IMPC
increased cardiac stroke volume / IMPC
increased fasting circulating glucose level / IMPC

IMPC phenotypes (gene matching)

dilated heart left ventricle / IMPC
abnormal salivary gland morphology / IMPC
increased red blood cell distribution width / IMPC
increased mean corpuscular hemoglobin / IMPC
enlarged thymus / IMPC
abnormal inspiratory capacity / IMPC
increased circulating bilirubin level / IMPC
increased neutrophil cell number / IMPC
decreased lung elastance / IMPC
no spontaneous movement / IMPC
small salivary gland / IMPC
increased cardiac output / IMPC
increased monocyte cell number / IMPC
increased lung compliance / IMPC
increased fasting circulating glucose level / IMPC
decreased circulating total protein level / IMPC
increased circulating potassium level / IMPC
increased cardiac stroke volume / IMPC

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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C57BL/6NCrl-Hycc1em1(IMPC)Ccpcz/Ph