STOCK Egr2tm2(cre)Pch/Orl

Status

Available to order

EMMA IDEM:11829
Citation informationRRID:IMSR_EM:11829 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameSTOCK Egr2tm2(cre)Pch/Orl
Alternative nameKrox20 cre
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolEgr2tm2(cre)Pch
Gene/Transgene symbolEgr2

Information from provider

ProviderCarole Desmarquet-Trin-Dinh
Provider affiliationEquipe Developpement du Systeme Nerveux IBENS, INSERM U 1024, CNRS UMR 8197, Ecole Normale Superieure
Genetic informationKnock-in insertion of cre gene in Krox20/Egr2 locus
Phenotypic informationHomozygous:
Nothing to report

Heterozygous:
Nothing to report
References
  • Expression pattern of a Krox-20/Cre knock-in allele in the developing hindbrain, bones, and peripheral nervous system.;Voiculescu O, Charnay P, Schneider-Maunoury S, ;2000;Genesis (New York, N.Y. : 2000);26;123-6; 10686605
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivingheterozygous (C57BL/6 x DBA/2)F1 males, wild-type (C57BL/6 x DBA/2)F1 females
Stage of embryos2-cell

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • abnormal mandible morphology / MGI
  • tremors / MGI
  • weakness / MGI
  • paralysis / MGI
  • hindlimb paralysis / MGI
  • abnormal myelination / MGI
  • abnormal rhombomere morphology / MGI
  • abnormal motor neuron morphology / MGI
  • abnormal spinal cord morphology / MGI
  • abnormal neuromuscular synapse morphology / MGI
  • abnormal cranial nerve morphology / MGI
  • abnormal trigeminal nerve morphology / MGI
  • abnormal abducens nerve morphology / MGI
  • abnormal facial nerve morphology / MGI
  • abnormal glossopharyngeal nerve morphology / MGI
  • abnormal vagus nerve morphology / MGI
  • abnormal cranial ganglia morphology / MGI
  • abnormal geniculate ganglion morphology / MGI
  • abnormal trigeminal ganglion morphology / MGI
  • abnormal glossopharyngeal ganglion morphology / MGI
  • abnormal vagus ganglion morphology / MGI
  • abnormal Schwann cell morphology / MGI
  • decreased body weight / MGI
  • weight loss / MGI
  • decreased body size / MGI
  • delayed eyelid opening / MGI
  • hypoactivity / MGI
  • impaired coordination / MGI
  • abnormal gait / MGI
  • impaired limb coordination / MGI
  • postnatal growth retardation / MGI
  • respiratory distress / MGI
  • abnormal motor capabilities/coordination/movement / MGI
  • abnormal skeleton development / MGI
  • abnormal neural tube morphology / MGI
  • abnormal sciatic nerve morphology / MGI
  • abnormal aortic valve morphology / MGI
  • abnormal somatic nervous system morphology / MGI
  • short tibia / MGI
  • abnormal cochlear ganglion morphology / MGI
  • abnormal bone mineralization / MGI
  • no phenotypic analysis / MGI
  • abnormal long bone epiphyseal plate morphology / MGI
  • short femur / MGI
  • decreased width of hypertrophic chondrocyte zone / MGI
  • abnormal long bone morphology / MGI
  • abnormal bone structure / MGI
  • short radius / MGI
  • fusion of glossopharyngeal and vagus nerve / MGI
  • decreased length of long bones / MGI
  • increased pulmonary respiratory rate / MGI
  • abnormal neuronal migration / MGI
  • abnormal hindbrain development / MGI
  • decreased diameter of long bones / MGI
  • decreased diameter of femur / MGI
  • decreased diameter of radius / MGI
  • decreased diameter of tibia / MGI
  • decreased nerve conduction velocity / MGI
  • enlarged aortic valve / MGI
  • thick aortic valve cusps / MGI
  • thick pulmonary valve cusps / MGI
  • integument phenotype / MGI
  • lethality at weaning, complete penetrance / MGI
  • postnatal lethality, complete penetrance / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • neonatal lethality, incomplete penetrance / MGI
  • increased Schwann cell proliferation / MGI
  • decreased rhombomere 3 size / MGI
  • absent rhombomere 3 / MGI
  • decreased rhombomere 5 size / MGI
  • absent rhombomere 5 / MGI
  • decreased rhombomere 6 size / MGI

Literature references

  • Expression pattern of a Krox-20/Cre knock-in allele in the developing hindbrain, bones, and peripheral nervous system.;Voiculescu O, Charnay P, Schneider-Maunoury S, ;2000;Genesis (New York, N.Y. : 2000);26;123-6; 10686605

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).