IMPC phenotypes (gene matching)
Sprague Dawley rat Rno11_DelApp/YahIcsOrl
| Status | Available to order |
| EMMA ID | EM:11820 |
| International strain name | Sprague Dawley rat Rno11_DelApp/YahIcsOrl |
| Alternative name | Sprague Dawley rat Rno11_Del |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Rno11 |
| Gene/Transgene symbol | App |
Information from provider
| Provider | Yann HERAULT |
| Provider affiliation | I.G.B.M.C. |
| Genetic information | Deletion by CRISPR/Cas9 system, of 43 bp at the end of exon 16 of the rat App gene. For the technic used on all our rat models see PMID: 28266534 |
| Phenotypic information | Homozygous:Growth delay but normal lifespanHeterozygous:No difference compared to control |
| Breeding history | 1 backcross on Sprague Dawley genetic background |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | wild-type rat Sprague-Dawley |
| Stage of embryos | 2-cell |
Disease and phenotype information
Literature references
- Efficient and rapid generation of large genomic variants in rats and mice using CRISMERE.;Birling Marie-Christine, Schaeffer Laurence, André Philippe, Lindner Loic, Maréchal Damien, Ayadi Abdel, Sorg Tania, Pavlovic Guillaume, Hérault Yann, ;2017;Scientific reports;7;43331; 28266534