D1.129P2(B6)-Il10tm1Cgn/JOrl

Status

Available to order

EMMA IDEM:11812
Citation informationRRID:IMSR_EM:11812 

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International strain nameD1.129P2(B6)-Il10tm1Cgn/JOrl
Alternative nameD1.B6-Il10tm1Cgn/J
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolIl10tm1Cgn
Gene/Transgene symbolIl10

Information from provider

ProviderPascale Plence
Provider affiliationINSERM U1183
Genetic informationA 500 bp genomic fragment containing codons 5-55 was replaced with a linker containing a termination codon followed by a neomycin cassette. A termination codon was also introduced into exon 3. Submitted mouse strain was obtained by backcrossing strain B6.129P2-Il10tm1Cgn/J, obtained by the Jackson Laboratory (strain ref. 002251), for 10 generations on DBA/1 background and followed by 3 intercrosses.
Phenotypic informationHomozygous:
Under conventional housing conditions, Il10-deficiency is associated with altered lymphocyte and myeloid profiles, elevated serum amyloid A levels, altered responses to inflammatory or autoimmune stimuli, increased prevalence of colorectal adenocarcinoma, and spontaneous development of chronic enterocolitis.

Heterozygous:
No phenotype
Breeding history10 backcrosses followed by 3 intercrosses
ReferencesNone available
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedyes

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivinghomozygous DBA/1 males

Disease and phenotype information

MGI allele-associated human disease models

Orphanet associated rare diseases, based on orthologous gene matching

    • Immune dysregulation-inflammatory bowel disease-arthritis-recurrent infections syndrome / Orphanet_238569
MGI phenotypes (gene matching)
  • abnormal trabecular bone morphology / MGI
  • abnormal circulating serum albumin level / MGI
  • absent erythroid progenitor cell / MGI
  • increased granulocyte number / MGI
  • abnormal enterocyte morphology / MGI
  • abnormal intestinal epithelium morphology / MGI
  • abnormal large intestine morphology / MGI
  • abnormal crypts of Lieberkuhn morphology / MGI
  • rectal prolapse / MGI
  • abnormal colon morphology / MGI
  • abnormal intestinal mucosa morphology / MGI
  • abnormal liver physiology / MGI
  • spleen hyperplasia / MGI
  • thymus hyperplasia / MGI
  • abnormal lymphocyte cell number / MGI
  • decreased body weight / MGI
  • impaired coordination / MGI
  • abnormal sleep pattern / MGI
  • abnormal skeleton physiology / MGI
  • abnormal lipid level / MGI
  • abnormal circulating enzyme level / MGI
  • anemia / MGI
  • abnormal myelopoiesis / MGI
  • postnatal growth retardation / MGI
  • abnormal homeostasis / MGI
  • abnormal iron level / MGI
  • abnormal immune system physiology / MGI
  • abnormal inflammatory response / MGI
  • intestinal inflammation / MGI
  • abnormal reproductive system physiology / MGI
  • increased thermal nociceptive threshold / MGI
  • decreased tumor incidence / MGI
  • abnormal glucose homeostasis / MGI
  • premature death / MGI
  • abnormal hypersensitivity reaction / MGI
  • no abnormal phenotype detected / MGI
  • decreased airway responsiveness / MGI
  • increased susceptibility to bacterial infection / MGI
  • abnormal innate immunity / MGI
  • increased IgE level / MGI
  • chronic inflammation / MGI
  • abnormal type IV hypersensitivity reaction / MGI
  • enhanced wound healing / MGI
  • decreased circulating insulin level / MGI
  • microcytic anemia / MGI
  • colitis / MGI
  • decreased hemoglobin content / MGI
  • decreased erythrocyte cell number / MGI
  • increased insulin sensitivity / MGI
  • abnormal bone mineralization / MGI
  • increased intestinal adenocarcinoma incidence / MGI
  • abnormal cytokine secretion / MGI
  • no phenotypic analysis / MGI
  • increased vasoconstriction / MGI
  • decreased vasoconstriction / MGI
  • increased myocardial infarction size / MGI
  • short femur / MGI
  • large intestinal inflammation / MGI
  • small intestinal inflammation / MGI
  • decreased susceptibility to induced choroidal neovascularization / MGI
  • abnormal bone structure / MGI
  • increased hepatocyte apoptosis / MGI
  • abnormal nitric oxide homeostasis / MGI
  • decreased circulating iron level / MGI
  • decreased incidence of tumors by UV induction / MGI
  • decreased length of allograft survival / MGI
  • abnormal neuron physiology / MGI
  • decreased mean systemic arterial blood pressure / MGI
  • abnormal regulatory T cell physiology / MGI
  • increased thymus weight / MGI
  • decreased bone strength / MGI
  • increased B cell number / MGI
  • increased T cell number / MGI
  • abnormal response to infection / MGI
  • increased susceptibility to parasitic infection / MGI
  • abnormal level of surface class II molecules / MGI
  • decreased T cell proliferation / MGI
  • cachexia / MGI
  • increased circulating cholesterol level / MGI
  • decreased circulating cholesterol level / MGI
  • increased fatty acid level / MGI
  • abnormal Langerhans cell physiology / MGI
  • immune system phenotype / MGI
  • abnormal circulating protein level / MGI
  • abnormal skeleton morphology / MGI
  • decreased circulating creatinine level / MGI
  • increased susceptibility to type IV hypersensitivity reaction / MGI
  • increased cerebral infarction size / MGI
  • increased CD4-positive, alpha beta T cell number / MGI
  • increased plasma cell number / MGI
  • increased myeloid dendritic cell number / MGI
  • increased susceptibility to neuronal excitotoxicity / MGI
  • abnormal leukocyte morphology / MGI
  • abnormal myeloid leukocyte morphology / MGI
  • hypochromic anemia / MGI
  • abnormal osteoblast differentiation / MGI
  • abnormal protein level / MGI
  • decreased spleen red pulp amount / MGI
  • slow postnatal weight gain / MGI
  • increased IgG1 level / MGI
  • increased IgG2a level / MGI
  • increased susceptibility to induced colitis / MGI
  • increased circulating tumor necrosis factor level / MGI
  • increased interferon-gamma secretion / MGI
  • increased circulating interferon-gamma level / MGI
  • decreased circulating interleukin-10 level / MGI
  • abnormal circulating interleukin-6 level / MGI
  • increased circulating interleukin-6 level / MGI
  • increased circulating interleukin-2 level / MGI
  • increased circulating interleukin-17 level / MGI
  • increased circulating interleukin-12 level / MGI
  • increased circulating interleukin-1 alpha level / MGI
  • increased circulating interleukin-1 beta level / MGI
  • abnormal circulating interleukin-12b level / MGI
  • abnormal cytokine level / MGI
  • abnormal chemokine level / MGI
  • increased susceptibility to endotoxin shock / MGI
  • abnormal interferon level / MGI
  • abnormal interleukin level / MGI
  • abnormal tumor necrosis factor level / MGI
  • abnormal placental labyrinth vasculature morphology / MGI
  • decreased spleen iron level / MGI
  • decreased physiological sensitivity to xenobiotic / MGI
  • increased large intestine adenocarcinoma incidence / MGI
  • increased colon adenocarcinoma incidence / MGI
  • decreased trabecular bone thickness / MGI
  • increased liver triglyceride level / MGI
  • cecum inflammation / MGI
  • increased sensitivity to induced morbidity/mortality / MGI
  • increased leukotriene level / MGI
  • decreased bone mineral content / MGI
  • abnormal intestine physiology / MGI
  • decreased bone trabecula number / MGI
  • decreased trabecular bone mass / MGI
  • decreased compact bone mass / MGI
  • impaired adaptive thermogenesis / MGI
  • increased placental labyrinth size / MGI
  • impaired exercise endurance / MGI
  • alveolar process atrophy / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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