- abnormal trabecular bone morphology / MGI
- abnormal circulating serum albumin level / MGI
- absent erythroid progenitor cell / MGI
- increased granulocyte number / MGI
- abnormal enterocyte morphology / MGI
- abnormal intestinal epithelium morphology / MGI
- abnormal large intestine morphology / MGI
- abnormal crypts of Lieberkuhn morphology / MGI
- rectal prolapse / MGI
- abnormal colon morphology / MGI
- abnormal intestinal mucosa morphology / MGI
- abnormal liver physiology / MGI
- spleen hyperplasia / MGI
- thymus hyperplasia / MGI
- abnormal lymphocyte cell number / MGI
- decreased body weight / MGI
- impaired coordination / MGI
- abnormal sleep pattern / MGI
- abnormal skeleton physiology / MGI
- abnormal lipid level / MGI
- abnormal circulating enzyme level / MGI
- anemia / MGI
- abnormal myelopoiesis / MGI
- postnatal growth retardation / MGI
- abnormal homeostasis / MGI
- abnormal iron level / MGI
- abnormal immune system physiology / MGI
- abnormal inflammatory response / MGI
- intestinal inflammation / MGI
- abnormal reproductive system physiology / MGI
- increased thermal nociceptive threshold / MGI
- decreased tumor incidence / MGI
- abnormal glucose homeostasis / MGI
- premature death / MGI
- abnormal hypersensitivity reaction / MGI
- no abnormal phenotype detected / MGI
- decreased airway responsiveness / MGI
- increased susceptibility to bacterial infection / MGI
- abnormal innate immunity / MGI
- increased IgE level / MGI
- chronic inflammation / MGI
- abnormal type IV hypersensitivity reaction / MGI
- enhanced wound healing / MGI
- decreased circulating insulin level / MGI
- microcytic anemia / MGI
- colitis / MGI
- decreased hemoglobin content / MGI
- decreased erythrocyte cell number / MGI
- increased insulin sensitivity / MGI
- abnormal bone mineralization / MGI
- increased intestinal adenocarcinoma incidence / MGI
- abnormal cytokine secretion / MGI
- no phenotypic analysis / MGI
- increased vasoconstriction / MGI
- decreased vasoconstriction / MGI
- increased myocardial infarction size / MGI
- short femur / MGI
- large intestinal inflammation / MGI
- small intestinal inflammation / MGI
- decreased susceptibility to induced choroidal neovascularization / MGI
- abnormal bone structure / MGI
- increased hepatocyte apoptosis / MGI
- abnormal nitric oxide homeostasis / MGI
- decreased circulating iron level / MGI
- decreased incidence of tumors by UV induction / MGI
- decreased length of allograft survival / MGI
- abnormal neuron physiology / MGI
- decreased mean systemic arterial blood pressure / MGI
- abnormal regulatory T cell physiology / MGI
- increased thymus weight / MGI
- decreased bone strength / MGI
- increased B cell number / MGI
- increased T cell number / MGI
- abnormal response to infection / MGI
- increased susceptibility to parasitic infection / MGI
- abnormal level of surface class II molecules / MGI
- decreased T cell proliferation / MGI
- cachexia / MGI
- increased circulating cholesterol level / MGI
- decreased circulating cholesterol level / MGI
- increased fatty acid level / MGI
- abnormal Langerhans cell physiology / MGI
- immune system phenotype / MGI
- abnormal circulating protein level / MGI
- abnormal skeleton morphology / MGI
- decreased circulating creatinine level / MGI
- increased susceptibility to type IV hypersensitivity reaction / MGI
- increased cerebral infarction size / MGI
- increased CD4-positive, alpha beta T cell number / MGI
- increased plasma cell number / MGI
- increased myeloid dendritic cell number / MGI
- increased susceptibility to neuronal excitotoxicity / MGI
- abnormal leukocyte morphology / MGI
- abnormal myeloid leukocyte morphology / MGI
- hypochromic anemia / MGI
- abnormal osteoblast differentiation / MGI
- abnormal protein level / MGI
- decreased spleen red pulp amount / MGI
- slow postnatal weight gain / MGI
- increased IgG1 level / MGI
- increased IgG2a level / MGI
- increased susceptibility to induced colitis / MGI
- increased circulating tumor necrosis factor level / MGI
- increased interferon-gamma secretion / MGI
- increased circulating interferon-gamma level / MGI
- decreased circulating interleukin-10 level / MGI
- abnormal circulating interleukin-6 level / MGI
- increased circulating interleukin-6 level / MGI
- increased circulating interleukin-2 level / MGI
- increased circulating interleukin-17 level / MGI
- increased circulating interleukin-12 level / MGI
- increased circulating interleukin-1 alpha level / MGI
- increased circulating interleukin-1 beta level / MGI
- abnormal circulating interleukin-12b level / MGI
- abnormal cytokine level / MGI
- abnormal chemokine level / MGI
- increased susceptibility to endotoxin shock / MGI
- abnormal interferon level / MGI
- abnormal interleukin level / MGI
- abnormal tumor necrosis factor level / MGI
- abnormal placental labyrinth vasculature morphology / MGI
- decreased spleen iron level / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- increased large intestine adenocarcinoma incidence / MGI
- increased colon adenocarcinoma incidence / MGI
- decreased trabecular bone thickness / MGI
- increased liver triglyceride level / MGI
- cecum inflammation / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- increased leukotriene level / MGI
- decreased bone mineral content / MGI
- abnormal intestine physiology / MGI
- decreased bone trabecula number / MGI
- decreased trabecular bone mass / MGI
- decreased compact bone mass / MGI
- impaired adaptive thermogenesis / MGI
- increased placental labyrinth size / MGI
- impaired exercise endurance / MGI
- alveolar process atrophy / MGI
D1.129P2(B6)-Il10tm1Cgn/JOrl
Status | Available to order |
EMMA ID | EM:11812 |
International strain name | D1.129P2(B6)-Il10tm1Cgn/JOrl |
Alternative name | D1.B6-Il10tm1Cgn/J |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Il10tm1Cgn |
Gene/Transgene symbol | Il10 |
Information from provider
Provider | Pascale Plence |
Provider affiliation | INSERM U1183 |
Genetic information | A 500 bp genomic fragment containing codons 5-55 was replaced with a linker containing a termination codon followed by a neomycin cassette. A termination codon was also introduced into exon 3. Submitted mouse strain was obtained by backcrossing strain B6.129P2-Il10tm1Cgn/J, obtained by the Jackson Laboratory (strain ref. 002251), for 10 generations on DBA/1 background and followed by 3 intercrosses. |
Phenotypic information | Homozygous:Under conventional housing conditions, Il10-deficiency is associated with altered lymphocyte and myeloid profiles, elevated serum amyloid A levels, altered responses to inflammatory or autoimmune stimuli, increased prevalence of colorectal adenocarcinoma, and spontaneous development of chronic enterocolitis.Heterozygous:No phenotype |
Breeding history | 10 backcrosses followed by 3 intercrosses |
References | None available |
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | yes |
Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Animals used for archiving | homozygous DBA/1 |
Disease and phenotype information
MGI allele-associated human disease models
Orphanet associated rare diseases, based on orthologous gene matching
- Immune dysregulation-inflammatory bowel disease-arthritis-recurrent infections syndrome / Orphanet_238569
MGI phenotypes (gene matching)
Information on how we integrate external resources can be found here
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