C57BL/6N-Grpel1tm1a(EUCOMM)Wtsi/Oulu
| Status | Available to order |
| EMMA ID | EM:11804 |
| International strain name | C57BL/6N-Grpel1tm1a(EUCOMM)Wtsi/Oulu |
| Alternative name | Grpel1tm1a(EUCOMM)Wtsi; GrpE-like 1, mitochondrial; targeted mutation 1a |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Grpel1tm1a(EUCOMM)Wtsi |
| Gene/Transgene symbol | Grpel1 |
Information from provider
| Provider | Henna Tyynismaa |
| Provider affiliation | Research Program for Molecular Neurology, University of Helsinki |
| Genetic information | Mutation details: The L1L2_Bact_P cassette was inserted at position 36468949 of chromosome 5 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 36469864. The critical exon(s) is/are thus flanked by loxP sites. ES cell clone EPD0158_3_F01. |
| Phenotypic information | Homozygous:Not analyzedHeterozygous:No obvious phenotype |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | not known |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Oulu, Oulu, Finland |
| Animals used for archiving | heterozygous C57BL/6NCrl, wild-type 0 |
| Stage of embryos | 2-cell |
Literature references
- Inter-organellar and systemic responses to impaired mitochondrial matrix protein import in skeletal muscle.;Neupane Nirajan, Rajendran Jayasimman, Kvist Jouni, Harjuhaahto Sandra, Hu Bowen, Kinnunen Veijo, Yang Yang, Nieminen Anni I, Tyynismaa Henna, ;2022;Communications biology;5;1060; 36198903