C57BL/6N-Grpel1tm1a(EUCOMM)Wtsi/Oulu

Status

Available to order

EMMA IDEM:11804
International strain nameC57BL/6N-Grpel1tm1a(EUCOMM)Wtsi/Oulu
Alternative nameGrpel1tm1a(EUCOMM)Wtsi; GrpE-like 1, mitochondrial; targeted mutation 1a
Strain typeTargeted Mutant Strains
Allele/Transgene symbolGrpel1tm1a(EUCOMM)Wtsi
Gene/Transgene symbolGrpel1

Information from provider

ProviderHenna Tyynismaa
Provider affiliationResearch Program for Molecular Neurology, University of Helsinki
Genetic informationMutation details: The L1L2_Bact_P cassette was inserted at position 36468949 of chromosome 5 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 36469864. The critical exon(s) is/are thus flanked by loxP sites. ES cell clone EPD0158_3_F01.
Phenotypic informationHomozygous:
Not analyzed

Heterozygous:
No obvious phenotype
References
  • Inter-organellar and systemic responses to impaired mitochondrial matrix protein import in skeletal muscle.;Neupane Nirajan, Rajendran Jayasimman, Kvist Jouni, Harjuhaahto Sandra, Hu Bowen, Kinnunen Veijo, Yang Yang, Nieminen Anni I, Tyynismaa Henna, ;2022;Communications biology;5;1060; 36198903
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requirednot known
Immunocompromisedno

Information from EMMA

Archiving centreUniversity of Oulu, Oulu, Finland
Animals used for archivingheterozygous C57BL/6NCrl, wild-type 0
Stage of embryos2-cell

Literature references

  • Inter-organellar and systemic responses to impaired mitochondrial matrix protein import in skeletal muscle.;Neupane Nirajan, Rajendran Jayasimman, Kvist Jouni, Harjuhaahto Sandra, Hu Bowen, Kinnunen Veijo, Yang Yang, Nieminen Anni I, Tyynismaa Henna, ;2022;Communications biology;5;1060; 36198903

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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