Sprague Dawley rat DelDyrk1a/YahIcsOrl

Status

Available to order

EMMA IDEM:11792
International strain nameSprague Dawley rat DelDyrk1a/YahIcsOrl
Alternative nameSprague Dawley rat Del
Strain typeEndonuclease-mediated
Allele/Transgene symbolUnknown at present
Gene/Transgene symbolDyrk1a

Information from provider

ProviderYann HERAULT
Provider affiliationTranslational Medicine and Neurogenetics, I.G.B.M.C.
Genetic informationSprague Dawley rat. Deletion of the entire coding sequence of Dyrk1a gene (121kb) using CRISPR/Cas9 engineering. For the technic used on all our rat models see PMID: 28266534
Phenotypic informationHomozygous:
Rat homozygous are not viable

Heterozygous:
Growth delay, craniofacial dysmorphies, susceptibility to epileptic seizures.
Breeding history1 backcross on Sprague Dawley background
References
  • Efficient and rapid generation of large genomic variants in rats and mice using CRISMERE.;Birling Marie-Christine, Schaeffer Laurence, André Philippe, Lindner Loic, Maréchal Damien, Ayadi Abdel, Sorg Tania, Pavlovic Guillaume, Hérault Yann, ;2017;Scientific reports;7;43331; 28266534
Homozygous fertileno
Homozygous viableno
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France
Animals used for archivingheterozygous rat Sprague-Dawley
Stage of embryos2-cell

Literature references

  • Efficient and rapid generation of large genomic variants in rats and mice using CRISMERE.;Birling Marie-Christine, Schaeffer Laurence, André Philippe, Lindner Loic, Maréchal Damien, Ayadi Abdel, Sorg Tania, Pavlovic Guillaume, Hérault Yann, ;2017;Scientific reports;7;43331; 28266534

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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