Sprague Dawley rat DelDyrk1a/YahIcsOrl
| Status | Available to order |
| EMMA ID | EM:11792 |
| International strain name | Sprague Dawley rat DelDyrk1a/YahIcsOrl |
| Alternative name | Sprague Dawley rat Del |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Unknown at present |
| Gene/Transgene symbol | Dyrk1a |
Information from provider
| Provider | Yann HERAULT |
| Provider affiliation | Translational Medicine and Neurogenetics, I.G.B.M.C. |
| Genetic information | Sprague Dawley rat. Deletion of the entire coding sequence of Dyrk1a gene (121kb) using CRISPR/Cas9 engineering. For the technic used on all our rat models see PMID: 28266534 |
| Phenotypic information | Homozygous:Rat homozygous are not viableHeterozygous:Growth delay, craniofacial dysmorphies, susceptibility to epileptic seizures. |
| Breeding history | 1 backcross on Sprague Dawley background |
| References |
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| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
| Animals used for archiving | heterozygous rat Sprague-Dawley |
| Stage of embryos | 2-cell |
Literature references
- Efficient and rapid generation of large genomic variants in rats and mice using CRISMERE.;Birling Marie-Christine, Schaeffer Laurence, André Philippe, Lindner Loic, Maréchal Damien, Ayadi Abdel, Sorg Tania, Pavlovic Guillaume, Hérault Yann, ;2017;Scientific reports;7;43331; 28266534