C57BL/6NCrl-Tent5a^{em1(IMPC)Ccpcz}/Ph

Status	Available to order
EMMA ID	EM:11774
International strain name	C57BL/6NCrl-Tent5a^{em1(IMPC)Ccpcz}/Ph
Alternative name
Strain type	Endonuclease-mediated
Allele/Transgene symbol	Tent5a^{em1(IMPC)Ccpcz}
Gene/Transgene symbol	Tent5a

Information from provider

Provider	Institute of Molecular Genetics
Provider affiliation	Department of Transgenic Models of Diseases, Institute of Molecular Genetics
Genetic information	This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	Institute of Molecular Genetics, Prague, Czech Republic
Animals used for archiving	heterozygous C57BL/6NCrl

Disease and phenotype information

IMPC phenotypes (allele matching)

abnormal scapula morphology / IMPC
abnormal rib morphology / IMPC
scoliosis / IMPC
increased leukocyte cell number / IMPC
increased neutrophil cell number / IMPC
increased monocyte cell number / IMPC
increased granulocyte number / IMPC
abnormal cranium morphology / IMPC
abnormal mandible morphology / IMPC
abnormal radius morphology / IMPC
abnormal tibia morphology / IMPC
abnormal femur morphology / IMPC
decreased body weight / IMPC
abnormal lens morphology / IMPC
increased anxiety-related response / IMPC
decreased locomotor activity / IMPC
abnormal gait / IMPC
decreased exploration in new environment / IMPC
impaired righting response / IMPC
abnormal tooth morphology / IMPC
abnormal fibula morphology / IMPC
short tibia / IMPC
abnormal joint morphology / IMPC
increased circulating alkaline phosphatase level / IMPC
abnormal bone structure / IMPC
abnormal spine curvature / IMPC
abnormal pelvic girdle bone morphology / IMPC
decreased lymphocyte cell number / IMPC
abnormal ulna morphology / IMPC
abnormal humerus morphology / IMPC
decreased circulating serum albumin level / IMPC
thrombocytosis / IMPC
decreased circulating glucose level / IMPC
increased circulating potassium level / IMPC
enhanced cued conditioning behavior / IMPC
decreased respiratory quotient / IMPC
decreased Ly6C-positive mature NK cell number / IMPC
increased freezing behavior / IMPC

IMPC phenotypes (gene matching)

decreased Ly6C-positive mature NK cell number / IMPC
abnormal bone structure / IMPC
abnormal ulna morphology / IMPC
abnormal tibia morphology / IMPC
abnormal tooth morphology / IMPC
abnormal cranium morphology / IMPC
impaired righting response / IMPC
abnormal joint morphology / IMPC
decreased locomotor activity / IMPC
abnormal femur morphology / IMPC
abnormal scapula morphology / IMPC
decreased body weight / IMPC
scoliosis / IMPC
increased neutrophil cell number / IMPC
abnormal spine curvature / IMPC
increased circulating potassium level / IMPC
decreased lymphocyte cell number / IMPC
abnormal humerus morphology / IMPC
abnormal lens morphology / IMPC
abnormal rib morphology / IMPC
increased circulating alkaline phosphatase level / IMPC
decreased exploration in new environment / IMPC
increased anxiety-related response / IMPC
abnormal pelvic girdle bone morphology / IMPC
abnormal fibula morphology / IMPC
increased freezing behavior / IMPC
abnormal radius morphology / IMPC
increased granulocyte number / IMPC
thrombocytosis / IMPC
decreased respiratory quotient / IMPC
enhanced cued conditioning behavior / IMPC
short tibia / IMPC
increased monocyte cell number / IMPC
increased leukocyte cell number / IMPC
decreased circulating glucose level / IMPC
decreased circulating serum albumin level / IMPC
abnormal mandible morphology / IMPC
abnormal gait / IMPC

MGI phenotypes (gene matching)

delayed bone ossification / MGI
fragile skeleton / MGI
abnormal scapula morphology / MGI
abnormal rib morphology / MGI
abnormal tibia morphology / MGI
abnormal femur morphology / MGI
decreased body height / MGI
decreased body size / MGI
abnormal gait / MGI
abnormal limb morphology / MGI
abnormal joint morphology / MGI
short femur / MGI
transmission ratio distortion / MGI
small scapula / MGI
short humerus / MGI
abnormal deltoid tuberosity morphology / MGI
abnormal ischium morphology / MGI
abnormal thoracic cage morphology / MGI
short ribs / MGI
small ischium / MGI
abnormal vertebral column morphology / MGI
abnormal humerus morphology / MGI
small cranium / MGI
skeleton phenotype / MGI
abnormal skeleton morphology / MGI
increased long bone epiphyseal plate size / MGI
increased diameter of femur / MGI
increased diameter of humerus / MGI
abnormal intramembranous bone ossification / MGI
abnormal calcaneum morphology / MGI
lethality, incomplete penetrance / MGI
absent bone trabeculae / MGI
increased alkaline phosphatase activity / MGI
decreased femur compact bone thickness / MGI
thin neurocranium / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

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C57BL/6NCrl-Tent5aem1(IMPC)Ccpcz/Ph