IMPC phenotypes (gene matching)
C57BL/6NTac-Hcn1em2(IMPC)H/H
| Status | Available to order |
| EMMA ID | EM:11725 |
| International strain name | C57BL/6NTac-Hcn1em2(IMPC)H/H |
| Alternative name | |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Hcn1em2(IMPC)H |
| Gene/Transgene symbol | Hcn1 |
Information from provider
| Provider | MRC, Medical Research Council |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | heterozygous C57BL/6N |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Undetermined early-onset epileptic encephalopathy / Orphanet_442835
- Generalized epilepsy with febrile seizures-plus / Orphanet_36387
MGI phenotypes (gene matching)
- abnormal spatial learning / MGI
- abnormal pain threshold / MGI
- abnormal learning/memory/conditioning / MGI
- no abnormal phenotype detected / MGI
- abnormal nervous system electrophysiology / MGI
- increased thigmotaxis / MGI
- abnormal motor learning / MGI
- abnormal eye blink conditioning behavior / MGI
- no phenotypic analysis / MGI
- abnormal depression-related behavior / MGI
- decreased cardiac output / MGI
- increased heart rate variability / MGI
- abnormal heartbeat / MGI
- abnormal myocardial fiber physiology / MGI
- behavior/neurological phenotype / MGI
- abnormal action potential / MGI
- abnormal sinoatrial node conduction / MGI
- abnormal RR interval / MGI
- sinoatrial block / MGI
- sinus bradycardia / MGI