- small salivary gland / MGI
- abnormal adrenal gland morphology / MGI
- abnormal sex gland morphology / MGI
- abnormal female reproductive system morphology / MGI
- small ovary / MGI
- abnormal ovarian follicle morphology / MGI
- absent mature ovarian follicles / MGI
- absent corpus luteum / MGI
- abnormal vagina epithelium morphology / MGI
- abnormal vagina orifice morphology / MGI
- abnormal male reproductive system morphology / MGI
- abnormal spermatogenesis / MGI
- decreased body weight / MGI
- male infertility / MGI
- female infertility / MGI
- abnormal gametogenesis / MGI
- abnormal spermiogenesis / MGI
- ovary cysts / MGI
- abnormal gland morphology / MGI
- delayed vaginal opening / MGI
- small uterus / MGI
- small male preputial glands / MGI
- abnormal male preputial gland morphology / MGI
- decreased circulating luteinizing hormone level / MGI
- absent ovarian follicles / MGI
- decreased circulating testosterone level / MGI
- decreased circulating follicle stimulating hormone level / MGI
- no phenotypic analysis / MGI
- absent sexual maturation / MGI
- decreased liver weight / MGI
- abnormal uterus development / MGI
- nervous system phenotype / MGI
- decreased kidney weight / MGI
- abnormal Sertoli cell development / MGI
- decreased testis weight / MGI
- decreased ovary weight / MGI
- decreased uterus weight / MGI
- seminal vesicle hypoplasia / MGI
- azoospermia / MGI
- decreased circulating estradiol level / MGI
- abnormal circulating estradiol level / MGI
- small penis / MGI
- abnormal anogenital distance / MGI
- Leydig cell hypoplasia / MGI
- abnormal spermatid morphology / MGI
- retention of the adrenal gland x-zone / MGI
- anovulation / MGI
- absent estrous cycle / MGI
- abnormal seminal vesicle development / MGI
129-Kiss1tm2(cre/GFP)Coll/H
Status | Available to order |
EMMA ID | EM:11714 |
International strain name | 129-Kiss1tm2(cre/GFP)Coll/H |
Alternative name | Kiss1-tm2(cre/GFP)Coll |
Strain type | Targeted Mutant Strains : Knock-in |
Allele/Transgene symbol | Kiss1tm2(cre/GFP)Coll |
Gene/Transgene symbol | Kiss1 |
Information from provider
Provider | William Colledge |
Provider affiliation | PDN, University of Cambridge |
Genetic information | Targeted disruption of Kiss1 gene with insertion of a fused CRE:GFP, the expression of which is driven from the Kiss1 promoter. |
Phenotypic information | Homozygous:Male and female sterilityHeterozygous:No obvious phenotype |
Breeding history | Chimaeras from 129S/SvEv ES cells were crossed with 129 mice from Taconic. |
References | None available |
Homozygous fertile | no |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Normosmic congenital hypogonadotropic hypogonadism / Orphanet_432
MGI phenotypes (gene matching)
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