129-Kiss1tm2(cre/GFP)Coll/H

Status

Available to order

EMMA IDEM:11714
Citation informationRRID:IMSR_EM:11714 

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International strain name129-Kiss1tm2(cre/GFP)Coll/H
Alternative nameKiss1-tm2(cre/GFP)Coll
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolKiss1tm2(cre/GFP)Coll
Gene/Transgene symbolKiss1

Information from provider

ProviderWilliam Colledge
Provider affiliationPDN, University of Cambridge
Genetic informationTargeted disruption of Kiss1 gene with insertion of a fused CRE:GFP, the expression of which is driven from the Kiss1 promoter.
Phenotypic informationHomozygous:
Male and female sterility

Heterozygous:
No obvious phenotype
Breeding historyChimaeras from 129S/SvEv ES cells were crossed with 129 mice from Taconic.
ReferencesNone available
Homozygous fertileno
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • Normosmic congenital hypogonadotropic hypogonadism / Orphanet_432
MGI phenotypes (gene matching)
  • small salivary gland / MGI
  • abnormal adrenal gland morphology / MGI
  • abnormal sex gland morphology / MGI
  • abnormal female reproductive system morphology / MGI
  • small ovary / MGI
  • abnormal ovarian follicle morphology / MGI
  • absent mature ovarian follicles / MGI
  • absent corpus luteum / MGI
  • abnormal vagina epithelium morphology / MGI
  • abnormal vagina orifice morphology / MGI
  • abnormal male reproductive system morphology / MGI
  • abnormal spermatogenesis / MGI
  • decreased body weight / MGI
  • male infertility / MGI
  • female infertility / MGI
  • abnormal gametogenesis / MGI
  • abnormal spermiogenesis / MGI
  • ovary cysts / MGI
  • abnormal gland morphology / MGI
  • delayed vaginal opening / MGI
  • small uterus / MGI
  • small male preputial glands / MGI
  • abnormal male preputial gland morphology / MGI
  • decreased circulating luteinizing hormone level / MGI
  • absent ovarian follicles / MGI
  • decreased circulating testosterone level / MGI
  • decreased circulating follicle stimulating hormone level / MGI
  • no phenotypic analysis / MGI
  • absent sexual maturation / MGI
  • decreased liver weight / MGI
  • abnormal uterus development / MGI
  • nervous system phenotype / MGI
  • decreased kidney weight / MGI
  • abnormal Sertoli cell development / MGI
  • decreased testis weight / MGI
  • decreased ovary weight / MGI
  • decreased uterus weight / MGI
  • seminal vesicle hypoplasia / MGI
  • azoospermia / MGI
  • decreased circulating estradiol level / MGI
  • abnormal circulating estradiol level / MGI
  • small penis / MGI
  • abnormal anogenital distance / MGI
  • Leydig cell hypoplasia / MGI
  • abnormal spermatid morphology / MGI
  • retention of the adrenal gland x-zone / MGI
  • anovulation / MGI
  • absent estrous cycle / MGI
  • abnormal seminal vesicle development / MGI

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
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Material Transfer Agreement (MTA)
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