- abnormal thymus morphology / IMPC
- increased circulating cholesterol level / IMPC
- increased exploration in new environment / IMPC
- decreased mean corpuscular hemoglobin / IMPC
- decreased hemoglobin content / IMPC
- enlarged lymph nodes / IMPC
- decreased mean corpuscular hemoglobin concentration / IMPC
- decreased mean corpuscular hemoglobin / IMPC
- abnormal lymph node morphology / IMPC
- decreased mean corpuscular volume / IMPC
- decreased circulating cholesterol level / IMPC
- abnormal skin condition / IMPC
- small testis / IMPC
- abnormal testis morphology / IMPC
- increased circulating total protein level / IMPC
- increased circulating HDL cholesterol level / IMPC
- decreased circulating free fatty acids level / IMPC
- enlarged heart / IMPC
- decreased circulating alkaline phosphatase level / IMPC
- decreased circulating HDL cholesterol level / IMPC
- abnormal heart morphology / IMPC
- enlarged thymus / IMPC
B6;129P2-Rhdtm1Goo Rhagtm1Goo/Orl
Status | Available to order |
EMMA ID | EM:11708 |
International strain name | B6;129P2-Rhdtm1Goo Rhagtm1Goo/Orl |
Alternative name | GOO1 x GOO2 also Rhdtm1GOOxRhagtm1GOO (MGI:5318588x5318589) |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Rhdtm1Goo, Rhagtm1Goo |
Gene/Transgene symbol | Rhd, Rhag |
Information from provider
Provider | Dominique GOOSSENS |
Provider affiliation | UMRS_1134-Inserm-Dept de recherches biologiques sur le globule rouge, Institut National de la Transfusion Sanguine- Inserm |
Genetic information | Rhd and Rhag (erythrocyte membrane proteins) gene knockout cross (double knockout). |
Phenotypic information | Homozygous:No clinical abnormalities, complete loss of Rhd and Rhag and mouse RH erythrocyte complex proteins, disruption of erythrocyte ammonium transport.Heterozygous:normal |
References |
|
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | yes |
Immunocompromised | no |
Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Animals used for archiving | homozygous 129 x C57BL/6, homozygous 129 x C57BL/6 |
Stage of embryos | 2-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Overhydrated hereditary stomatocytosis / Orphanet_3203
- Rh deficiency syndrome / Orphanet_71275
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- abnormal erythrocyte physiology / MGI
- increased circulating iron level / MGI
- abnormal blood homeostasis / MGI
- decreased mean corpuscular volume / MGI
- decreased hemoglobin content / MGI
- abnormal erythrocyte physiology / MGI
- decreased mean corpuscular hemoglobin concentration / MGI
- increased circulating iron level / MGI
Literature references
- Generation and characterisation of Rhd and Rhag null mice.;Goossens Dominique, Trinh-Trang-Tan Marie-Marcelle, Debbia Martine, Ripoche Pierre, Vilela-Lamego Camilo, Louache Fawzia, Vainchenker William, Colin Yves, Cartron Jean-Pierre, ;2010;British journal of haematology;148;161-72; 19807729
- Generation of mice with inactivated Rh or Rhag genes.;Goossens D, Bony V, Gane P, Colin Y, Cartron J-P, ;2006;Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine;13;164-6; 16581281
- Role of RhAG and AQP1 in NH3 and CO2 gas transport in red cell ghosts: a stopped-flow analysis.;Ripoche P, Goossens D, Devuyst O, Gane P, Colin Y, Verkman A S, Cartron J-P, ;2006;Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine;13;117-22; 16574458
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