IMPC phenotypes (gene matching)
B6.Cg-Mtortm1.1Gcon Eif4ebp1tm1Nso Eif4ebp2tm1Klan A1cfTg(Myh6-cre/Esr1*)1Jmk/Cnrm
| Status | Available to order |
| EMMA ID | EM:11705 |
| International strain name | B6.Cg-Mtortm1.1Gcon Eif4ebp1tm1Nso Eif4ebp2tm1Klan A1cfTg(Myh6-cre/Esr1*)1Jmk/Cnrm |
| Alternative name | ME |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | A1cfTg(Myh6-cre/Esr1*)1Jmk, Mtortm1.1Gcon, Eif4ebp1tm1Nso, Eif4ebp2tm1Klan |
| Gene/Transgene symbol | A1cf, Mtor, Eif4ebp1, Eif4ebp2 |
Information from provider
| Provider | Gianluigi Condorelli |
| Provider affiliation | Laboratory of Inflammation and Immunology in Cardiovascular Pathologies, Istituto Clinico Humanitas |
| Genetic information | B6/129 mTOR fl; 4EBP1-4EBP2 KO; MHC-MerCreMer Tg. These mTOR floxed mutant mice harbor loxP sites flanking exons 1-5 and the Cre recombinase is activated after Tamoxifen injection. Furthermore these mice are global KO for the eukaryotic translation initiation factor 4E binding protein 1 (4EBP1 Chr8) and 2 (4EBP2, Chr10). |
| Phenotypic information | Homozygous:No harmful phenotype.Heterozygous:No harmful phenotype. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | yes |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Isolated focal cortical dysplasia type IIa / Orphanet_269001
- Isolated focal cortical dysplasia type IIb / Orphanet_269008
- Macrocephaly-intellectual disability-neurodevelopmental disorder-small thorax syndrome / Orphanet_457485
MGI phenotypes (gene matching)
- decreased cell proliferation / MGI
- embryonic lethality before implantation, complete penetrance / MGI
- hypoglycemia / MGI
- decreased body weight / MGI
- decreased white adipose tissue amount / MGI
- abnormal myocardial fiber physiology / MGI
- increased oxygen consumption / MGI
- homeostasis/metabolism phenotype / MGI
- increased cardiac muscle contractility / MGI
- abnormal cell physiology / MGI
- decreased circulating leptin level / MGI
- abnormal white adipose tissue physiology / MGI
- decreased gonadal fat pad weight / MGI
- decreased inguinal fat pad weight / MGI
- decreased retroperitoneal fat pad weight / MGI
- decreased total body fat amount / MGI
- abnormal social investigation / MGI
- increased stereotypic behavior / MGI
- increased grooming behavior / MGI
- abnormal spatial learning / MGI
- abnormal vocalization / MGI
- abnormal associative learning / MGI
- abnormal CNS synaptic transmission / MGI
- abnormal long term potentiation / MGI
- abnormal inhibitory postsynaptic currents / MGI
- abnormal miniature excitatory postsynaptic currents / MGI
- abnormal hippocampus CA1 region morphology / MGI
- abnormal miniature inhibitory postsynaptic currents / MGI
- abnormal hippocampus pyramidal cell morphology / MGI
- increased excitatory postsynaptic current amplitude / MGI
- increased circulating LDL cholesterol level / MGI
- decreased circulating LDL cholesterol level / MGI
- decreased neutrophil cell number / MGI
- decreased monocyte cell number / MGI
- small spleen / MGI
- decreased thymocyte number / MGI
- abnormal forebrain morphology / MGI
- forebrain hypoplasia / MGI
- abnormal diencephalon morphology / MGI
- abnormal midbrain morphology / MGI
- decreased body weight / MGI
- decreased body size / MGI
- abnormal gastrulation / MGI
- decreased embryo size / MGI
- incomplete embryo turning / MGI
- embryonic growth arrest / MGI
- abnormal humoral immune response / MGI
- decreased IgG level / MGI
- decreased IgM level / MGI
- abnormal developmental patterning / MGI
- abnormal embryonic tissue morphology / MGI
- abnormal extraembryonic tissue morphology / MGI
- abnormal muscle physiology / MGI
- abnormal B cell differentiation / MGI
- no abnormal phenotype detected / MGI
- abnormal T cell physiology / MGI
- abnormal B cell physiology / MGI
- small ectoplacental cone / MGI
- no phenotypic analysis / MGI
- decreased lean body mass / MGI
- embryonic growth retardation / MGI
- abnormal embryonic neuroepithelium morphology / MGI
- decreased circulating insulin-like growth factor I level / MGI
- inner cell mass degeneration / MGI
- decreased B cell number / MGI
- abnormal trophoblast layer morphology / MGI
- abnormal trophoblast giant cell morphology / MGI
- decreased double-positive T cell number / MGI
- decreased B cell proliferation / MGI
- growth/size/body region phenotype / MGI
- immune system phenotype / MGI
- increased mean corpuscular hemoglobin / MGI
- decreased blood urea nitrogen level / MGI
- abnormal T cell morphology / MGI
- increased CD4-positive, alpha beta T cell number / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- increased CD8-positive, alpha-beta T cell number / MGI
- decreased plasma cell number / MGI
- decreased follicular B cell number / MGI
- decreased marginal zone B cell number / MGI
- embryonic lethality / MGI
- decreased splenocyte proliferation / MGI
- decreased splenocyte number / MGI
- decreased splenocyte apoptosis / MGI
- decreased transitional stage T1 B cell number / MGI
- increased total body fat amount / MGI
- decreased skeletal muscle weight / MGI
- prenatal lethality, complete penetrance / MGI
- embryonic lethality, complete penetrance / MGI
- embryonic lethality between implantation and somite formation, complete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- preweaning lethality, incomplete penetrance / MGI
- absent inner cell mass proliferation / MGI
- absent embryonic telencephalon / MGI
Literature references
- The translation repressor 4E-BP2 is critical for eIF4F complex formation, synaptic plasticity, and memory in the hippocampus.;Banko Jessica L, Poulin Francis, Hou Lingfei, DeMaria Christine T, Sonenberg Nahum, Klann Eric, ;2005;The Journal of neuroscience : the official journal of the Society for Neuroscience;25;9581-90; 16237163
- MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice.;Zhang Denghong, Contu Riccardo, Latronico Michael V G, Zhang Jianlin, Rizzi Roberto, Catalucci Daniele, Miyamoto Shigeki, Huang Katherine, Ceci Marcello, Gu Yusu, Dalton Nancy D, Peterson Kirk L, Guan Kun-Liang, Brown Joan Heller, Chen Ju, Sonenberg Nahum, Condorelli Gianluigi, ;2010;The Journal of clinical investigation;120;2805-16; 20644257