IMPC phenotypes (gene matching)
B6.Cg-Mtortm1.1Gcon Eif4ebp1tm1Nso Eif4ebp2tm1Klan A1cfTg(Myh6-cre/Esr1*)1Jmk/Cnrm
| Status | Available to order |
| EMMA ID | EM:11705 |
| Citation information | RRID:IMSR_EM:11705 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Mtortm1.1Gcon Eif4ebp1tm1Nso Eif4ebp2tm1Klan A1cfTg(Myh6-cre/Esr1*)1Jmk/Cnrm |
| Alternative name | ME |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | A1cfTg(Myh6-cre/Esr1*)1Jmk, Mtortm1.1Gcon, Eif4ebp1tm1Nso, Eif4ebp2tm1Klan |
| Gene/Transgene symbol | A1cf, Mtor, Eif4ebp1, Eif4ebp2 |
Information from provider
| Provider | Gianluigi Condorelli |
| Provider affiliation | Laboratory of Inflammation and Immunology in Cardiovascular Pathologies, Istituto Clinico Humanitas |
| Genetic information | B6/129 mTOR fl; 4EBP1-4EBP2 KO; MHC-MerCreMer Tg. These mTOR floxed mutant mice harbor loxP sites flanking exons 1-5 and the Cre recombinase is activated after Tamoxifen injection. Furthermore these mice are global KO for the eukaryotic translation initiation factor 4E binding protein 1 (4EBP1 Chr8) and 2 (4EBP2, Chr10). |
| Phenotypic information | Homozygous:No harmful phenotype.Heterozygous:No harmful phenotype. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | yes |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Isolated focal cortical dysplasia type IIa / Orphanet_269001
- Isolated focal cortical dysplasia type IIb / Orphanet_269008
- Macrocephaly-intellectual disability-neurodevelopmental disorder-small thorax syndrome / Orphanet_457485
MGI phenotypes (gene matching)
- decreased cell proliferation / MGI
- embryonic lethality before implantation, complete penetrance / MGI
- hypoglycemia / MGI
- decreased body weight / MGI
- decreased white adipose tissue amount / MGI
- abnormal myocardial fiber physiology / MGI
- increased oxygen consumption / MGI
- homeostasis/metabolism phenotype / MGI
- increased cardiac muscle contractility / MGI
- abnormal cell physiology / MGI
- decreased circulating leptin level / MGI
- abnormal white adipose tissue physiology / MGI
- decreased gonadal fat pad weight / MGI
- decreased inguinal fat pad weight / MGI
- decreased retroperitoneal fat pad weight / MGI
- decreased total body fat amount / MGI
- abnormal social investigation / MGI
- increased stereotypic behavior / MGI
- increased grooming behavior / MGI
- abnormal spatial learning / MGI
- abnormal vocalization / MGI
- abnormal associative learning / MGI
- abnormal CNS synaptic transmission / MGI
- abnormal long term potentiation / MGI
- abnormal inhibitory postsynaptic currents / MGI
- abnormal miniature excitatory postsynaptic currents / MGI
- abnormal hippocampus CA1 region morphology / MGI
- abnormal miniature inhibitory postsynaptic currents / MGI
- abnormal hippocampus pyramidal cell morphology / MGI
- increased excitatory postsynaptic current amplitude / MGI
- increased circulating LDL cholesterol level / MGI
- decreased circulating LDL cholesterol level / MGI
- decreased neutrophil cell number / MGI
- decreased monocyte cell number / MGI
- small spleen / MGI
- decreased thymocyte number / MGI
- abnormal forebrain morphology / MGI
- forebrain hypoplasia / MGI
- abnormal diencephalon morphology / MGI
- abnormal midbrain morphology / MGI
- decreased body weight / MGI
- decreased body size / MGI
- abnormal gastrulation / MGI
- decreased embryo size / MGI
- incomplete embryo turning / MGI
- embryonic growth arrest / MGI
- abnormal humoral immune response / MGI
- decreased IgG level / MGI
- decreased IgM level / MGI
- abnormal developmental patterning / MGI
- abnormal embryonic tissue morphology / MGI
- abnormal extraembryonic tissue morphology / MGI
- abnormal muscle physiology / MGI
- abnormal B cell differentiation / MGI
- no abnormal phenotype detected / MGI
- abnormal T cell physiology / MGI
- abnormal B cell physiology / MGI
- small ectoplacental cone / MGI
- no phenotypic analysis / MGI
- decreased lean body mass / MGI
- embryonic growth retardation / MGI
- abnormal embryonic neuroepithelium morphology / MGI
- decreased circulating insulin-like growth factor I level / MGI
- inner cell mass degeneration / MGI
- decreased B cell number / MGI
- abnormal trophoblast layer morphology / MGI
- abnormal trophoblast giant cell morphology / MGI
- decreased double-positive T cell number / MGI
- decreased B cell proliferation / MGI
- growth/size/body region phenotype / MGI
- immune system phenotype / MGI
- increased mean corpuscular hemoglobin / MGI
- decreased blood urea nitrogen level / MGI
- abnormal T cell morphology / MGI
- increased CD4-positive, alpha beta T cell number / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- increased CD8-positive, alpha-beta T cell number / MGI
- decreased plasma cell number / MGI
- decreased follicular B cell number / MGI
- decreased marginal zone B cell number / MGI
- embryonic lethality / MGI
- decreased splenocyte proliferation / MGI
- decreased splenocyte number / MGI
- decreased splenocyte apoptosis / MGI
- decreased transitional stage T1 B cell number / MGI
- increased total body fat amount / MGI
- decreased skeletal muscle weight / MGI
- prenatal lethality, complete penetrance / MGI
- embryonic lethality, complete penetrance / MGI
- embryonic lethality between implantation and somite formation, complete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- preweaning lethality, incomplete penetrance / MGI
- absent inner cell mass proliferation / MGI
- absent embryonic telencephalon / MGI
Literature references
- The translation repressor 4E-BP2 is critical for eIF4F complex formation, synaptic plasticity, and memory in the hippocampus.;Banko Jessica L, Poulin Francis, Hou Lingfei, DeMaria Christine T, Sonenberg Nahum, Klann Eric, ;2005;The Journal of neuroscience : the official journal of the Society for Neuroscience;25;9581-90; 16237163
- MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice.;Zhang Denghong, Contu Riccardo, Latronico Michael V G, Zhang Jianlin, Rizzi Roberto, Catalucci Daniele, Miyamoto Shigeki, Huang Katherine, Ceci Marcello, Gu Yusu, Dalton Nancy D, Peterson Kirk L, Guan Kun-Liang, Brown Joan Heller, Chen Ju, Sonenberg Nahum, Condorelli Gianluigi, ;2010;The Journal of clinical investigation;120;2805-16; 20644257