B6NCrl;B6N-Atm1Brd Ltn1tm1a(EUCOMM)Hmgu/Ph

Status

Available to order

EMMA IDEM:11689
International strain nameB6NCrl;B6N-Atm1Brd Ltn1tm1a(EUCOMM)Hmgu/Ph
Alternative nameHEPD0658_5_C10
Strain typeTargeted Mutant Strains
Allele/Transgene symbolLtn1tm1a(EUCOMM)Hmgu
Gene/Transgene symbolLtn1
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Institute of Molecular Genetics
Provider affiliationDepartment of Transgenic Models of Diseases, Institute of Molecular Genetics
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0658_5_C10. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitute of Molecular Genetics, Prague, Czech Republic
Animals used for archivingheterozygous C57BL/6NCrl

Disease and phenotype information

IMPC phenotypes (gene matching)
  • increased lung tissue damping / IMPC
  • increased lung elastance / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
  • abnormal cornea morphology / IMPC
  • increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
  • thrombocytopenia / IMPC
  • decreased circulating alkaline phosphatase level / IMPC
  • increased airway resistance / IMPC
  • no spontaneous movement / IMPC
  • increased freezing behavior / IMPC
  • increased red blood cell distribution width / IMPC
  • decreased body weight / IMPC
MGI phenotypes (gene matching)
  • abnormal muscle regeneration / MGI
  • paralysis / MGI
  • motor neuron degeneration / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • limb grasping / MGI
  • abnormal motor coordination/balance / MGI
  • impaired righting response / MGI
  • impaired balance / MGI
  • abnormal motor capabilities/coordination/movement / MGI
  • muscular atrophy / MGI
  • abnormal neuron morphology / MGI
  • neuron degeneration / MGI
  • astrocytosis / MGI
  • abnormal physical strength / MGI
  • abnormal neuron physiology / MGI
  • bradykinesia / MGI
  • abnormal neurite morphology / MGI
  • slow postnatal weight gain / MGI
  • embryonic lethality / MGI
  • weaving / MGI
  • decreased skeletal muscle fiber size / MGI
  • paraparesis / MGI
  • decreased grip strength / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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