DW-Lepr^db-Pas/Orl

Status	Available to order
EMMA ID	EM:01167
International strain name	DW-Lepr^db-Pas/Orl
Alternative name	diabete-Pasteur
Strain type	Spontaneous
Allele/Transgene symbol	Lepr^db-Pas
Gene/Transgene symbol	Lepr

Information from provider

Provider	Jean-Louis Guénet
Provider affiliation	Institut Pasteur
Genetic information	Southern analysis indicates that the mutation in the Pas allele is a partial duplication of the coding sequence for the putative extracellular domain of the Lepr protein.
Phenotypic information	Obesity.
Breeding history	Bred by crossing heterozygous mice.
References	A mutation in the DW inbred line producting an obese phenotype;Guenet JL;1982;Mouse News Lett.;67;30; 3882910 Description of a new model of genetic obesity: the dbPas mouse.;Aubert R, Herzog J, Camus M C, Guenet J L, Lemonnier D, ;1985;The Journal of nutrition;115;327-33;

Information from EMMA

Archiving centre	Institut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

MGI allele-associated human disease models

obesity / DOID:9970

Orphanet associated rare diseases, based on orthologous gene matching

Obesity due to leptin receptor gene deficiency / Orphanet_179494

IMPC phenotypes (gene matching)

increased circulating serum albumin level / IMPC
increased circulating total protein level / IMPC
increased red blood cell distribution width / IMPC
increased neutrophil cell number / IMPC
decreased leukocyte cell number / IMPC
decreased circulating chloride level / IMPC
decreased locomotor activity / IMPC
increased circulating alanine transaminase level / IMPC
increased circulating phosphate level / IMPC
decreased lymphocyte cell number / IMPC
decreased bone mineral density / IMPC
decreased lean body mass / IMPC
increased hematocrit / IMPC
abnormal gait / IMPC
increased circulating triglyceride level / IMPC
female infertility / IMPC
increased total body fat amount / IMPC
increased circulating glucose level / IMPC
male infertility / IMPC
increased mean corpuscular hemoglobin / IMPC
decreased bone mineral content / IMPC
thrombocytopenia / IMPC
impaired righting response / IMPC
trunk curl / IMPC
increased circulating calcium level / IMPC
increased circulating alkaline phosphatase level / IMPC
increased eosinophil cell number / IMPC
tremors / IMPC
increased anxiety-related response / IMPC
increased circulating potassium level / IMPC
decreased spleen weight / IMPC
abnormal locomotor behavior / IMPC
enlarged liver / IMPC
increased circulating HDL cholesterol level / IMPC
increased circulating aspartate transaminase level / IMPC
increased circulating fructosamine level / IMPC
small seminal vesicle / IMPC
limb grasping / IMPC
increased hemoglobin content / IMPC
increased circulating amylase level / IMPC
increased monocyte cell number / IMPC
increased circulating cholesterol level / IMPC
decreased heart weight / IMPC
increased mean corpuscular volume / IMPC
increased mean platelet volume / IMPC
decreased exploration in new environment / IMPC
increased circulating iron level / IMPC
abnormal bone structure / IMPC

MGI phenotypes (allele matching)

increased brown adipose tissue amount / MGI
short tail / MGI
enlarged liver / MGI
enlarged spleen / MGI
obese / MGI
polyphagia / MGI
hyperglycemia / MGI
male infertility / MGI
female infertility / MGI
increased circulating insulin level / MGI
short femur / MGI
decreased muscle weight / MGI
increased circulating cholesterol level / MGI
increased total body fat amount / MGI

MGI phenotypes (gene matching)

abnormal adipose tissue morphology / MGI
increased brown adipose tissue amount / MGI
abnormal circulating cholesterol level / MGI
increased circulating LDL cholesterol level / MGI
abnormal circulating glucose level / MGI
hypoglycemia / MGI
increased neutrophil cell number / MGI
decreased leukocyte cell number / MGI
abnormal vascular development / MGI
abnormal myocardial fiber morphology / MGI
altered response to myocardial infarction / MGI
abnormal intestinal epithelium morphology / MGI
short tail / MGI
enlarged liver / MGI
enlarged adrenal glands / MGI
absent adrenal medulla / MGI
enlarged spleen / MGI
decreased motor neuron number / MGI
abnormal female reproductive system morphology / MGI
abnormal uterus morphology / MGI
constricted vagina orifice / MGI
increased body length / MGI
decreased body length / MGI
increased body weight / MGI
obese / MGI
decreased body weight / MGI
weight loss / MGI
increased body size / MGI
increased metastatic potential / MGI
reduced male mating frequency / MGI
hypoactivity / MGI
polydipsia / MGI
abnormal eating behavior / MGI
polyphagia / MGI
abnormal spatial learning / MGI
reduced long term potentiation / MGI
abnormal cardiovascular system physiology / MGI
abnormal lipid level / MGI
hyperlipidemia / MGI
increased circulating triglyceride level / MGI
increased circulating free fatty acid level / MGI
increased circulating HDL cholesterol level / MGI
hyperglycemia / MGI
abnormal circulating insulin level / MGI
extended life span / MGI
abnormal digestive system physiology / MGI
increased circulating corticosterone level / MGI
increased urine glucose level / MGI
polyuria / MGI
liver inflammation / MGI
lung inflammation / MGI
pancreas inflammation / MGI
abnormal lactation / MGI
absent long term depression / MGI
reduced male fertility / MGI
reduced female fertility / MGI
infertility / MGI
male infertility / MGI
female infertility / MGI
abnormal estrous cycle / MGI
abnormal learning/memory/conditioning / MGI
abnormal glucose homeostasis / MGI
increased circulating insulin level / MGI
premature death / MGI
abnormal skeleton development / MGI
abnormal blood circulation / MGI
abnormal kidney morphology / MGI
no abnormal phenotype detected / MGI
abnormal CNS synaptic transmission / MGI
abnormal functional residual capacity / MGI
abnormal respiratory mechanics / MGI
abnormal lung compliance / MGI
abnormal CD4-positive, alpha beta T cell morphology / MGI
increased IgE level / MGI
abnormal acute inflammation / MGI
heart left ventricle hypertrophy / MGI
hepatic steatosis / MGI
small uterus / MGI
decreased circulating triglyceride level / MGI
decreased corpora lutea number / MGI
decreased mature ovarian follicle number / MGI
abnormal pancreas physiology / MGI
increased glucagon secretion / MGI
increased circulating glucagon level / MGI
small male preputial glands / MGI
decreased circulating insulin level / MGI
abnormal conditioned taste aversion behavior / MGI
decreased systemic arterial blood pressure / MGI
albuminuria / MGI
increased insulin sensitivity / MGI
delayed wound healing / MGI
abnormal inhibitory postsynaptic currents / MGI
increased urine protein level / MGI
increased liver weight / MGI
no phenotypic analysis / MGI
increased vasoconstriction / MGI
increased insulin secretion / MGI
decreased insulin secretion / MGI
short femur / MGI
increased susceptibility to age related obesity / MGI
abnormal locomotor activation / MGI
abnormal gluconeogenesis / MGI
decreased cardiac output / MGI
abnormal pancreatic beta cell physiology / MGI
abnormal insulin secretion / MGI
abnormal nervous system morphology / MGI
abnormal response/metabolism to endogenous compounds / MGI
increased pancreatic beta cell number / MGI
abnormal axon extension / MGI
maternal effect / MGI
increased left ventricle diastolic pressure / MGI
abnormal myelin sheath morphology / MGI
increased kidney weight / MGI
abnormal circulating lipid level / MGI
abnormal hormone level / MGI
decreased lean body mass / MGI
cardiac ischemia / MGI
abnormal kidney papilla morphology / MGI
abnormal kidney calyx morphology / MGI
decreased muscle weight / MGI
enlarged placenta / MGI
increased susceptibility to autoimmune diabetes / MGI
increased mean systemic arterial blood pressure / MGI
abnormal vascular wound healing / MGI
decreased adiponectin level / MGI
abnormal endometrium morphology / MGI
decreased uterus weight / MGI
abnormal behavior / MGI
abnormal CD8-positive, alpha beta T cell morphology / MGI
increased susceptibility to parasitic infection / MGI
decreased T cell proliferation / MGI
decreased follicle stimulating hormone level / MGI
decreased cardiac muscle contractility / MGI
increased circulating VLDL cholesterol level / MGI
increased circulating cholesterol level / MGI
abnormal pancreatic islet morphology / MGI
abnormal pancreatic beta cell morphology / MGI
abnormal exocrine pancreas morphology / MGI
abnormal intraocular pressure / MGI
glomerulosclerosis / MGI
abnormal oxygen consumption / MGI
increased oxygen consumption / MGI
decreased oxygen consumption / MGI
improved glucose tolerance / MGI
impaired glucose tolerance / MGI
abnormal renal glomerulus morphology / MGI
abnormal myocardium layer morphology / MGI
insulin resistance / MGI
decreased heart rate / MGI
abnormal fat pad morphology / MGI
homeostasis/metabolism phenotype / MGI
growth/size/body region phenotype / MGI
reproductive system phenotype / MGI
abnormal nerve conduction / MGI
abnormal axon morphology / MGI
decreased oocyte number / MGI
abnormal food intake / MGI
abnormal energy expenditure / MGI
increased susceptibility to weight gain / MGI
increased percent body fat/body weight / MGI
pancreatic islet hyperplasia / MGI
decreased body temperature / MGI
abnormal body temperature / MGI
decreased urine albumin level / MGI
abnormal eye electrophysiology / MGI
increased creatinine clearance / MGI
increased circulating glucose level / MGI
decreased circulating glucose level / MGI
decreased pulmonary ventilation / MGI
periinsulitis / MGI
abnormal hypothalamus physiology / MGI
increased susceptibility to diet-induced obesity / MGI
decreased circulating leptin level / MGI
increased circulating leptin level / MGI
decreased systemic arterial systolic blood pressure / MGI
abnormal epididymal fat pad morphology / MGI
increased glycosylated hemoglobin level / MGI
decreased CD4-positive, alpha beta T cell number / MGI
abnormal leukocyte morphology / MGI
abnormal adrenal gland zona reticularis morphology / MGI
abnormal osteoclast differentiation / MGI
abnormal spatial reference memory / MGI
increased circulating interleukin-6 level / MGI
increased interleukin-6 secretion / MGI
abnormal chemokine level / MGI
abnormal chemokine secretion / MGI
increased susceptibility to endotoxin shock / MGI
abnormal interleukin level / MGI
increased blood uric acid level / MGI
anovulation / MGI
increased enterocyte apoptosis / MGI
decreased carbon dioxide production / MGI
delayed estrous cycle / MGI
absent estrous cycle / MGI
abnormal diestrus / MGI
abnormal metestrus / MGI
absent estrus / MGI
increased pancreatic beta cell mass / MGI
increased pancreatic alpha cell number / MGI
degranulated pancreatic beta cells / MGI
decreased gonadal fat pad weight / MGI
increased mesenteric fat pad weight / MGI
decreased splenocyte number / MGI
increased liver triglyceride level / MGI
increased birth weight / MGI
increased sensitivity to induced morbidity/mortality / MGI
decreased prostaglandin level / MGI
increased total body fat amount / MGI
increased omental fat pad weight / MGI
decreased respiratory quotient / MGI
increased liver glycogen level / MGI
increased bone volume / MGI
abnormal respiratory electron transport chain / MGI
abnormal aerobic respiration / MGI
abnormal circadian temperature homeostasis / MGI
impaired adaptive thermogenesis / MGI
expanded mesangial matrix / MGI
increased food intake / MGI
decreased cell death / MGI
increased pancreatic islet cell apoptosis / MGI
decreased response to antigen / MGI
increased susceptibility to non-insulin-dependent diabetes / MGI
adipose tissue inflammation / MGI
abnormal locomotor circadian rhythm / MGI
renal glomerular protein deposits / MGI
renal glomerular immunoglobulin deposits / MGI

Literature references

A mutation in the DW inbred line producting an obese phenotype;Guenet JL;1982;Mouse News Lett.;67;30; 3882910
Description of a new model of genetic obesity: the dbPas mouse.;Aubert R, Herzog J, Camus M C, Guenet J L, Lemonnier D, ;1985;The Journal of nutrition;115;327-33;

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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DW-Leprdb-Pas/Orl