IMPC phenotypes (allele matching)
C57BL/6N-Gsk3atm1b(EUCOMM)Hmgu/Ieg
| Status | Available to order |
| EMMA ID | EM:11665 |
| International strain name | C57BL/6N-Gsk3atm1b(EUCOMM)Hmgu/Ieg |
| Alternative name | HEPD0506_1_B11 |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Gsk3atm1b(EUCOMM)Hmgu |
| Gene/Transgene symbol | Gsk3a |
| Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
| Provider | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH) |
| Provider affiliation | Institute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH) |
| Genetic information | This mouse line originates from EUCOMM ES clone HEPD0506_1_B11. For further details on the construction of this clone see the page at the IMPC portal. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele. Click here for more information on EUCOMM final vectors. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | heterozygous C57BL/6NTac |
Disease and phenotype information
IMPC phenotypes (gene matching)
- abnormal snout morphology / IMPC
- decreased circulating fructosamine level / IMPC
- improved glucose tolerance / IMPC
- decreased mean platelet volume / IMPC
- increased circulating alkaline phosphatase level / IMPC
- prolonged QRS complex duration / IMPC
- abnormal gait / IMPC
- decreased startle reflex / IMPC
- decreased body weight / IMPC
- decreased total body fat amount / IMPC
- increased lean body mass / IMPC
- decreased body length / IMPC
- decreased exploration in new environment / IMPC
- decreased circulating glucose level / IMPC
- decreased lean body mass / IMPC
MGI phenotypes (gene matching)
- decreased body length / MGI
- decreased body weight / MGI
- no abnormal phenotype detected / MGI
- increased insulin sensitivity / MGI
- no phenotypic analysis / MGI
- decreased circulating glycerol level / MGI
- increased lean body mass / MGI
- decreased lumbar vertebrae number / MGI
- improved glucose tolerance / MGI
- homeostasis/metabolism phenotype / MGI
- craniofacial phenotype / MGI
- decreased percent body fat/body weight / MGI
- decreased circulating glucose level / MGI
- decreased total body fat amount / MGI
- increased sacral vertebrae number / MGI
- increased liver glycogen level / MGI
- wide metopic suture / MGI