IMPC phenotypes (allele matching)
- decreased circulating calcium level / IMPC
C57BL/6NTac-Shank3em1(IMPC)H/H
| Status | Available to order |
| EMMA ID | EM:11648 |
| Citation information | RRID:IMSR_EM:11648 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6NTac-Shank3em1(IMPC)H/H |
| Alternative name | |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Shank3em1(IMPC)H |
| Gene/Transgene symbol | Shank3 |
Information from provider
| Provider | MRC, Medical Research Council |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
IMPC phenotypes (gene matching)
- decreased circulating calcium level / IMPC
MGI phenotypes (gene matching)
- abnormal autopod morphology / MGI
- thalamus hyperplasia / MGI
- skin lesions / MGI
- increased body weight / MGI
- decreased body weight / MGI
- increased aggression towards mice / MGI
- abnormal social investigation / MGI
- social withdrawal / MGI
- increased anxiety-related response / MGI
- decreased anxiety-related response / MGI
- hyperactivity / MGI
- hypoactivity / MGI
- impaired coordination / MGI
- abnormal gait / MGI
- increased stereotypic behavior / MGI
- abnormal response to new environment / MGI
- decreased exploration in new environment / MGI
- increased grooming behavior / MGI
- abnormal object recognition memory / MGI
- abnormal spatial learning / MGI
- reduced long term potentiation / MGI
- reduced long term depression / MGI
- abnormal startle reflex / MGI
- increased startle reflex / MGI
- decreased startle reflex / MGI
- abnormal motor coordination/balance / MGI
- impaired righting response / MGI
- abnormal vocalization / MGI
- abnormal long term depression / MGI
- impaired synaptic plasticity / MGI
- reduced NMDA-mediated synaptic currents / MGI
- abnormal motor capabilities/coordination/movement / MGI
- abnormal brain commissure morphology / MGI
- abnormal CNS synaptic transmission / MGI
- abnormal nervous system electrophysiology / MGI
- abnormal social/conspecific interaction / MGI
- increased vertical activity / MGI
- decreased vertical activity / MGI
- increased thigmotaxis / MGI
- abnormal long term object recognition memory / MGI
- abnormal motor learning / MGI
- abnormal conditioned emotional response / MGI
- abnormal glutamate-mediated receptor currents / MGI
- abnormal excitatory postsynaptic currents / MGI
- abnormal excitatory postsynaptic potential / MGI
- decreased synaptic depression / MGI
- decreased post-tetanic potentiation / MGI
- no phenotypic analysis / MGI
- abnormal response to novelty / MGI
- abnormal response to novel object / MGI
- abnormal single cell response / MGI
- nervous system phenotype / MGI
- abnormal synaptic transmission / MGI
- abnormal ear development / MGI
- decreased thermal nociceptive threshold / MGI
- abnormal striatum morphology / MGI
- abnormal miniature excitatory postsynaptic currents / MGI
- abnormal paired-pulse inhibition / MGI
- abnormal neuron physiology / MGI
- abnormal behavior / MGI
- behavior/neurological phenotype / MGI
- taste/olfaction phenotype / MGI
- hyporesponsive to tactile stimuli / MGI
- abnormal basal ganglion morphology / MGI
- abnormal brain white matter morphology / MGI
- abnormal brain internal capsule morphology / MGI
- abnormal cingulum morphology / MGI
- small hippocampus / MGI
- abnormal spatial reference memory / MGI
- abnormal medium spiny neuron morphology / MGI
- induced hyperactivity / MGI
- environmentally induced seizures / MGI
- abnormal miniature inhibitory postsynaptic currents / MGI
- enhanced contextual conditioning behavior / MGI
- abnormal synapse morphology / MGI
- abnormal odor adaptation / MGI
- abnormal spinal cord commissure morphology / MGI
- abnormal dendritic spine morphology / MGI
- abnormal olfactory lobe morphology / MGI
- abnormal cerebellar peduncle morphology / MGI
- decreased grip strength / MGI
- integument phenotype / MGI
- lethality, incomplete penetrance / MGI
- abnormal allogrooming behavior / MGI
- decreased excitatory postsynaptic current amplitude / MGI
- abnormal innate avoidance response / MGI
- impaired spatial learning / MGI
- impaired learning / MGI
- decreased amygdala size / MGI
- photophobia / MGI
- decreased vocalization / MGI
- abnormal postsynaptic density morphology / MGI