IMPC phenotypes (gene matching)
- decreased circulating calcium level / IMPC
C57BL/6NTac-Shank3em2(IMPC)H/H
| Status | Available to order |
| EMMA ID | EM:11647 |
| International strain name | C57BL/6NTac-Shank3em2(IMPC)H/H |
| Alternative name | |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Shank3em2(IMPC)H |
| Gene/Transgene symbol | Shank3 |
Information from provider
| Provider | MRC, Medical Research Council |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | heterozygous C57BL/6NTacUSA, heterozygous C57BL/6N |
Disease and phenotype information
MGI phenotypes (gene matching)
- abnormal autopod morphology / MGI
- thalamus hyperplasia / MGI
- skin lesions / MGI
- increased body weight / MGI
- decreased body weight / MGI
- increased aggression towards mice / MGI
- abnormal social investigation / MGI
- social withdrawal / MGI
- increased anxiety-related response / MGI
- decreased anxiety-related response / MGI
- hyperactivity / MGI
- hypoactivity / MGI
- impaired coordination / MGI
- abnormal gait / MGI
- increased stereotypic behavior / MGI
- abnormal response to new environment / MGI
- decreased exploration in new environment / MGI
- increased grooming behavior / MGI
- abnormal object recognition memory / MGI
- abnormal spatial learning / MGI
- reduced long term potentiation / MGI
- reduced long term depression / MGI
- abnormal startle reflex / MGI
- increased startle reflex / MGI
- decreased startle reflex / MGI
- abnormal motor coordination/balance / MGI
- impaired righting response / MGI
- abnormal vocalization / MGI
- abnormal long term depression / MGI
- impaired synaptic plasticity / MGI
- reduced NMDA-mediated synaptic currents / MGI
- abnormal motor capabilities/coordination/movement / MGI
- abnormal brain commissure morphology / MGI
- abnormal CNS synaptic transmission / MGI
- abnormal nervous system electrophysiology / MGI
- abnormal social/conspecific interaction / MGI
- increased vertical activity / MGI
- decreased vertical activity / MGI
- increased thigmotaxis / MGI
- abnormal long term object recognition memory / MGI
- abnormal motor learning / MGI
- abnormal conditioned emotional response / MGI
- abnormal glutamate-mediated receptor currents / MGI
- abnormal excitatory postsynaptic currents / MGI
- abnormal excitatory postsynaptic potential / MGI
- decreased synaptic depression / MGI
- decreased post-tetanic potentiation / MGI
- no phenotypic analysis / MGI
- abnormal response to novelty / MGI
- abnormal response to novel object / MGI
- abnormal single cell response / MGI
- nervous system phenotype / MGI
- abnormal synaptic transmission / MGI
- abnormal ear development / MGI
- decreased thermal nociceptive threshold / MGI
- abnormal striatum morphology / MGI
- abnormal miniature excitatory postsynaptic currents / MGI
- abnormal paired-pulse inhibition / MGI
- abnormal neuron physiology / MGI
- abnormal behavior / MGI
- behavior/neurological phenotype / MGI
- taste/olfaction phenotype / MGI
- hyporesponsive to tactile stimuli / MGI
- abnormal basal ganglion morphology / MGI
- abnormal brain white matter morphology / MGI
- abnormal brain internal capsule morphology / MGI
- abnormal cingulum morphology / MGI
- small hippocampus / MGI
- abnormal spatial reference memory / MGI
- abnormal medium spiny neuron morphology / MGI
- induced hyperactivity / MGI
- environmentally induced seizures / MGI
- abnormal miniature inhibitory postsynaptic currents / MGI
- enhanced contextual conditioning behavior / MGI
- abnormal synapse morphology / MGI
- abnormal odor adaptation / MGI
- abnormal spinal cord commissure morphology / MGI
- abnormal dendritic spine morphology / MGI
- abnormal olfactory lobe morphology / MGI
- abnormal cerebellar peduncle morphology / MGI
- decreased grip strength / MGI
- integument phenotype / MGI
- lethality, incomplete penetrance / MGI
- abnormal allogrooming behavior / MGI
- decreased excitatory postsynaptic current amplitude / MGI
- abnormal innate avoidance response / MGI
- impaired spatial learning / MGI
- impaired learning / MGI
- decreased amygdala size / MGI
- photophobia / MGI
- decreased vocalization / MGI
- abnormal postsynaptic density morphology / MGI