IMPC phenotypes (gene matching)
129-Pik3cbtm1.1Bvan/Cnbc
| Status | Available to order |
| EMMA ID | EM:11633 |
| International strain name | 129-Pik3cbtm1.1Bvan/Cnbc |
| Alternative name | p110beta PI3K-DEL21/22(129) |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Pik3cbtm1.1Bvan |
| Gene/Transgene symbol | Pik3cb |
Information from provider
| Provider | Bart Vanhaesebroeck |
| Provider affiliation | UCL Cancer Institute, University College London |
| Additional owner | the University of Edinburgh |
| Genetic information | Mice in which exons 21 and 22 from Pik3cb/p110beta are constitutively deleted by crossing to a cre-deleter strain - backcrossed onto 129 background. |
| Phenotypic information | Homozygous:Homozygous Pik3cb/p110beta D21-22/D21-22 mice can be obtained but at reduced frequency, it depends on the genetic background.Heterozygous:Mice show reduced phenotypes of homozygous. |
| Breeding history | Backcrossed onto 129Sv for more than 10 generations. |
| References |
|
| Homozygous fertile | females only |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous 129S2/SvPasCrl |
Disease and phenotype information
MGI phenotypes (gene matching)
- decreased body weight / MGI
- weight loss / MGI
- decreased embryo size / MGI
- postnatal growth retardation / MGI
- decreased circulating triglyceride level / MGI
- increased insulin secretion / MGI
- abnormal gluconeogenesis / MGI
- decreased lumbar vertebrae number / MGI
- decreased circulating cholesterol level / MGI
- insulin resistance / MGI
- decreased heart rate / MGI
- decreased glycogen level / MGI
- abnormal platelet physiology / MGI
- pancreatic islet hyperplasia / MGI
- decreased circulating creatinine level / MGI
- increased circulating glucose level / MGI
- increased mean corpuscular hemoglobin / MGI
- increased hemoglobin content / MGI
- increased lung weight / MGI
- pulmonary fibrosis / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- decreased platelet aggregation / MGI
- decreased birth body size / MGI
- decreased sensitivity to xenobiotic induced morbidity/mortality / MGI
- embryonic lethality between somite formation and embryo turning, complete penetrance / MGI
- preweaning lethality, complete penetrance / MGI
- embryonic lethality, incomplete penetrance / MGI
- embryonic lethality before implantation, incomplete penetrance / MGI
- embryonic lethality during organogenesis, incomplete penetrance / MGI
- lethality throughout fetal growth and development, incomplete penetrance / MGI
- decreased fibroblast proliferation / MGI
Literature references
- The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma.;Guillermet-Guibert Julie, Bjorklof Katja, Salpekar Ashreena, Gonella Cristiano, Ramadani Faruk, Bilancio Antonio, Meek Stephen, Smith Andrew J H, Okkenhaug Klaus, Vanhaesebroeck Bart, ;2008;Proceedings of the National Academy of Sciences of the United States of America;105;8292-7; 18544649