IMPC phenotypes (gene matching)
B6.129P2-Pik3cbtm1(lacz-D931A)Bvan/Cnbc
| Status | Available to order |
| EMMA ID | EM:11632 |
| International strain name | B6.129P2-Pik3cbtm1(lacz-D931A)Bvan/Cnbc |
| Alternative name | p110beta PI3K-D931A-LacZ |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Pik3cbtm1(lacz-D931A)Bvan |
| Gene/Transgene symbol | Pik3cb |
Information from provider
| Provider | Bart Vanhaesebroeck |
| Provider affiliation | UCL Cancer Institute, University College London |
| Additional owner | the University of Edinburgh |
| Genetic information | An IRES-lacZ-MC1-neo marker/selection cassette, flanked by loxP sites, was inserted after the STOP codon in the last exon (24) of Pik3cb/p110beta PI3K. Knock-in with lacZ cassette. |
| Phenotypic information | Homozygous:Have not been characterised in detail as homo- or heterozygous express lacZ under the control of the Pik3cb/p110beta PI3K promotor.Heterozygous:Mice show reduced phenotypes of homozygous. LacZ expression is reduced compared with homozygotes. |
| Breeding history | Backcrossed onto C57BL/6J for more than 10 generations. |
| References | None available |
| Homozygous fertile | females only |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous C57BL/6OlaHsd |
Disease and phenotype information
MGI phenotypes (gene matching)
- decreased body weight / MGI
- weight loss / MGI
- decreased embryo size / MGI
- postnatal growth retardation / MGI
- decreased circulating triglyceride level / MGI
- increased insulin secretion / MGI
- abnormal gluconeogenesis / MGI
- decreased lumbar vertebrae number / MGI
- decreased circulating cholesterol level / MGI
- insulin resistance / MGI
- decreased heart rate / MGI
- decreased glycogen level / MGI
- abnormal platelet physiology / MGI
- pancreatic islet hyperplasia / MGI
- decreased circulating creatinine level / MGI
- increased circulating glucose level / MGI
- increased mean corpuscular hemoglobin / MGI
- increased hemoglobin content / MGI
- increased lung weight / MGI
- pulmonary fibrosis / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- decreased platelet aggregation / MGI
- decreased birth body size / MGI
- decreased sensitivity to xenobiotic induced morbidity/mortality / MGI
- embryonic lethality between somite formation and embryo turning, complete penetrance / MGI
- preweaning lethality, complete penetrance / MGI
- embryonic lethality, incomplete penetrance / MGI
- embryonic lethality before implantation, incomplete penetrance / MGI
- embryonic lethality during organogenesis, incomplete penetrance / MGI
- lethality throughout fetal growth and development, incomplete penetrance / MGI
- decreased fibroblast proliferation / MGI