C57BL/6N-Atm1Brd Hbs1ltm1a(KOMP)Wtsi/WtsiH

Status

Available to order

EMMA IDEM:11622
International strain nameC57BL/6N-Atm1Brd Hbs1ltm1a(KOMP)Wtsi/WtsiH
Alternative nameEPD0693_2_A02
Strain typeTargeted Mutant Strains
Allele/Transgene symbolHbs1ltm1a(KOMP)Wtsi
Gene/Transgene symbolHbs1l
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from KOMP ES clone EPD0693_2_A02. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (allele matching)
  • increased leukocyte cell number / IMPC
  • decreased monocyte cell number / IMPC
  • abnormal cranium morphology / IMPC
  • abnormal snout morphology / IMPC
  • corneal opacity / IMPC
  • abnormal retina morphology / IMPC
  • increased circulating free fatty acids level / IMPC
  • increased circulating HDL cholesterol level / IMPC
  • male infertility / IMPC
  • abnormal tail morphology / IMPC
  • increased mean platelet volume / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • vertebral transformation / IMPC
  • abnormal bone structure / IMPC
  • increased regulatory T cell number / IMPC
  • increased circulating cholesterol level / IMPC
  • improved glucose tolerance / IMPC
  • thrombocytosis / IMPC
  • increased mean corpuscular hemoglobin / IMPC
  • increased circulating total protein level / IMPC
  • decreased Langerhans cell number / IMPC
  • decreased mature B cell number / IMPC
  • increased circulating iron level / IMPC
  • decreased total body fat amount / IMPC
  • decreased bone mineral content / IMPC
  • increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
  • increased CD4-positive, alpha-beta memory T cell number / IMPC
  • increased effector memory CD8-positive, alpha-beta T cell number / IMPC
  • decreased effector memory CD8-positive, alpha-beta T cell number / IMPC
  • increased CD5-positive gamma-delta T cell number / IMPC
  • increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
  • decreased memory-marker CD4-negative NK T cell number / IMPC
  • decreased T-helper cell number / IMPC
IMPC phenotypes (gene matching)
  • abnormal retina morphology / IMPC
  • decreased total body fat amount / IMPC
  • increased circulating free fatty acids level / IMPC
  • decreased effector memory CD8-positive, alpha-beta T cell number / IMPC
  • decreased monocyte cell number / IMPC
  • increased regulatory T cell number / IMPC
  • increased effector memory CD8-positive, alpha-beta T cell number / IMPC
  • increased mean platelet volume / IMPC
  • thrombocytosis / IMPC
  • decreased memory-marker CD4-negative NK T cell number / IMPC
  • increased CD4-positive, alpha-beta memory T cell number / IMPC
  • abnormal snout morphology / IMPC
  • increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
  • male infertility / IMPC
  • increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
  • abnormal tail morphology / IMPC
  • decreased mature B cell number / IMPC
  • increased circulating total protein level / IMPC
  • increased mean corpuscular hemoglobin / IMPC
  • decreased T-helper cell number / IMPC
  • improved glucose tolerance / IMPC
  • decreased bone mineral content / IMPC
  • abnormal cranium morphology / IMPC
  • increased circulating HDL cholesterol level / IMPC
  • increased CD5-positive gamma-delta T cell number / IMPC
  • increased circulating cholesterol level / IMPC
  • increased circulating iron level / IMPC
  • abnormal bone structure / IMPC
  • decreased Langerhans cell number / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • vertebral transformation / IMPC
  • increased leukocyte cell number / IMPC
  • corneal opacity / IMPC

Information on how we integrate external resources can be found here

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
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Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

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