IMPC phenotypes (gene matching)
B6.129-Jarid2Gt(pGT1.8geo)6Pgr/Cnrm
| Status | Under development - register interest |
| EMMA ID | EM:00116 |
| Citation information | RRID:IMSR_EM:00116 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129-Jarid2Gt(pGT1.8geo)6Pgr/Cnrm |
| Alternative name | Jmj-Q15-gt |
| Strain type | Gene-trap |
| Allele/Transgene symbol | Jarid2Gt(pGT1.8geo)6Pgr |
| Gene/Transgene symbol | Jarid2 |
Information from provider
| Provider | Peter Gruss |
| Provider affiliation | Max Planck Inst. Biophysical Chemistry |
| Genetic information | This allele resulted from the insertion of a gene trap vector into the coding sequence of the gene. This independently derived allele is similar to the original jumonji gene trap allele (Jarid2jumonji). |
| Breeding history | Backcrossed to C57BL/6 (10 generations) |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Non-specific syndromic intellectual disability / Orphanet_528084
MGI phenotypes (gene matching)
- abnormal sternum morphology / MGI
- abnormal erythropoiesis / MGI
- abnormal heart development / MGI
- abnormal myocardial fiber morphology / MGI
- abnormal interventricular septum morphology / MGI
- double outlet right ventricle / MGI
- distended pericardium / MGI
- trabecula carnea hypoplasia / MGI
- abnormal liver morphology / MGI
- liver hypoplasia / MGI
- small liver / MGI
- enlarged liver sinusoidal spaces / MGI
- decreased hepatocyte number / MGI
- abnormal liver physiology / MGI
- spleen hypoplasia / MGI
- incomplete rostral neuropore closure / MGI
- anemia / MGI
- hepatic necrosis / MGI
- decreased embryo size / MGI
- edema / MGI
- thymus hypoplasia / MGI
- hemorrhage / MGI
- respiratory failure / MGI
- prenatal lethality / MGI
- abnormal definitive hematopoiesis / MGI
- abnormal neural tube morphology / MGI
- abnormal myocardial trabeculae morphology / MGI
- abnormal megakaryocyte progenitor cell morphology / MGI
- delayed neural tube closure / MGI
- thin myocardium / MGI
- abnormal fetal cardiomyocyte proliferation / MGI
- nervous system phenotype / MGI
- abnormal neural tube closure / MGI
- abnormal nervous system development / MGI
- abnormal heart left ventricle morphology / MGI
- abnormal interventricular groove morphology / MGI
- abnormal myocardium compact layer morphology / MGI
- dilated heart right atrium / MGI
- fetal growth retardation / MGI
- abnormal thoracic cage morphology / MGI
- abnormal neural fold formation / MGI
- abnormal myocardium layer morphology / MGI
- increased circulating creatinine level / MGI
- abnormal neural plate morphology / MGI
- abnormal splenic cell ratio / MGI
- abnormal thymus cell ratio / MGI
- ventricular septal defect / MGI
- abnormal coronary vessel morphology / MGI
- perinatal lethality, complete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- lethality throughout fetal growth and development, complete penetrance / MGI
- embryonic lethality during organogenesis, incomplete penetrance / MGI
- lethality throughout fetal growth and development, incomplete penetrance / MGI
- decreased fetal derived definitive erythrocyte cell number / MGI
Literature references
- Efficiency assessment of the gene trap approach.;Voss A K, Thomas T, Gruss P, ;1998;Developmental dynamics : an official publication of the American Association of Anatomists;212;171-80; 9626493