B6.129-Jarid2Gt(pGT1.8geo)6Pgr/Cnrm
Status | Available to order |
EMMA ID | EM:00116 |
International strain name | B6.129-Jarid2Gt(pGT1.8geo)6Pgr/Cnrm |
Alternative name | Jmj-Q15-gt |
Strain type | Gene-trap |
Allele/Transgene symbol | Jarid2Gt(pGT1.8geo)6Pgr |
Gene/Transgene symbol | Jarid2 |
Information from provider
Provider | Peter Gruss |
Provider affiliation | Max Planck Inst. Biophysical Chemistry |
Genetic information | This allele resulted from the insertion of a gene trap vector into the coding sequence of the gene. This independently derived allele is similar to the original jumonji gene trap allele (Jarid2jumonji). |
Breeding history | Backcrossed to C57BL/6 (10 generations) |
References |
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Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Non-specific syndromic intellectual disability / Orphanet_528084
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- abnormal sternum morphology / MGI
- abnormal erythropoiesis / MGI
- abnormal heart development / MGI
- abnormal myocardial fiber morphology / MGI
- abnormal interventricular septum morphology / MGI
- double outlet right ventricle / MGI
- distended pericardium / MGI
- trabecula carnea hypoplasia / MGI
- abnormal liver morphology / MGI
- liver hypoplasia / MGI
- small liver / MGI
- enlarged liver sinusoidal spaces / MGI
- decreased hepatocyte number / MGI
- abnormal liver physiology / MGI
- spleen hypoplasia / MGI
- incomplete rostral neuropore closure / MGI
- anemia / MGI
- hepatic necrosis / MGI
- decreased embryo size / MGI
- edema / MGI
- thymus hypoplasia / MGI
- hemorrhage / MGI
- respiratory failure / MGI
- prenatal lethality / MGI
- abnormal definitive hematopoiesis / MGI
- abnormal neural tube morphology / MGI
- abnormal myocardial trabeculae morphology / MGI
- abnormal megakaryocyte progenitor cell morphology / MGI
- delayed neural tube closure / MGI
- thin myocardium / MGI
- abnormal fetal cardiomyocyte proliferation / MGI
- nervous system phenotype / MGI
- abnormal neural tube closure / MGI
- abnormal nervous system development / MGI
- abnormal heart left ventricle morphology / MGI
- abnormal interventricular groove morphology / MGI
- abnormal myocardium compact layer morphology / MGI
- dilated heart right atrium / MGI
- fetal growth retardation / MGI
- abnormal thoracic cage morphology / MGI
- abnormal neural fold formation / MGI
- abnormal myocardium layer morphology / MGI
- increased circulating creatinine level / MGI
- abnormal neural plate morphology / MGI
- abnormal splenic cell ratio / MGI
- abnormal thymus cell ratio / MGI
- ventricular septal defect / MGI
- abnormal coronary vessel morphology / MGI
- perinatal lethality, complete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- lethality throughout fetal growth and development, complete penetrance / MGI
- embryonic lethality during organogenesis, incomplete penetrance / MGI
- lethality throughout fetal growth and development, incomplete penetrance / MGI
- decreased fetal derived definitive erythrocyte cell number / MGI
Literature references
- Efficiency assessment of the gene trap approach.;Voss A K, Thomas T, Gruss P, ;1998;Developmental dynamics : an official publication of the American Association of Anatomists;212;171-80; 9626493
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