C57BL/6N-Atm1Brd Flvcr2tm1a(EUCOMM)Hmgu/WtsiOulu

Status

Available to order

EMMA IDEM:11568
International strain nameC57BL/6N-Atm1Brd Flvcr2tm1a(EUCOMM)Hmgu/WtsiOulu
Alternative nameHEPD0572_8_F01
Strain typeTargeted Mutant Strains
Allele/Transgene symbolFlvcr2tm1a(EUCOMM)Hmgu
Gene/Transgene symbolFlvcr2
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0572_8_F01. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreUniversity of Oulu, Oulu, Finland

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (allele matching)
  • increased circulating LDL cholesterol level / IMPC
  • increased circulating HDL cholesterol level / IMPC
  • increased circulating cholesterol level / IMPC
  • preweaning lethality, complete penetrance / IMPC
IMPC phenotypes (gene matching)
  • increased circulating LDL cholesterol level / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • increased circulating HDL cholesterol level / IMPC
  • increased circulating cholesterol level / IMPC
MGI phenotypes (allele matching)
  • abnormal lung morphology / MGI
  • abnormal vein morphology / MGI
  • abnormal Wolffian duct morphology / MGI
  • abnormal inferior vena cava morphology / MGI
  • dual inferior vena cava / MGI
  • thin hypoglossal nerve / MGI
  • abnormal hypoglossal nerve topology / MGI
  • absent segment of posterior cerebral artery / MGI
  • hepatic portal vein stenosis / MGI
  • abnormal Mullerian duct topology / MGI
  • absent ductus venosus valve / MGI
  • abnormal ductus venosus valve morphology / MGI
  • blood in lymph vessels / MGI
  • embryo tumor / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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