C57BL/6N-Atm1Brd Kifap3tm1a(KOMP)Wtsi/WtsiOulu

Status

Available to order

EMMA IDEM:11555
International strain nameC57BL/6N-Atm1Brd Kifap3tm1a(KOMP)Wtsi/WtsiOulu
Alternative nameEPD0320_1_E08
Strain typeTargeted Mutant Strains
Allele/Transgene symbolKifap3tm1a(KOMP)Wtsi
Gene/Transgene symbolKifap3
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from KOMP ES clone EPD0320_1_E08. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreUniversity of Oulu, Oulu, Finland

Disease and phenotype information

IMPC phenotypes (allele matching)
  • impaired glucose tolerance / IMPC
  • preweaning lethality, complete penetrance / IMPC
IMPC phenotypes (gene matching)
  • impaired glucose tolerance / IMPC
  • preweaning lethality, complete penetrance / IMPC
MGI phenotypes (gene matching)
  • abnormal heart morphology / MGI
  • enlarged heart / MGI
  • abnormal thymus morphology / MGI
  • small thymus / MGI
  • decreased thymocyte number / MGI
  • weakness / MGI
  • abnormal medulla oblongata morphology / MGI
  • abnormal dorsal root ganglion morphology / MGI
  • abnormal trigeminal ganglion morphology / MGI
  • cyanosis / MGI
  • edema / MGI
  • abnormal myocardial trabeculae morphology / MGI
  • increased liver weight / MGI
  • abnormal heart atrium morphology / MGI
  • increased cardiomyocyte apoptosis / MGI
  • decreased skin turgor / MGI
  • abnormal heart ventricle morphology / MGI
  • abnormal myocardium layer morphology / MGI
  • increased lung weight / MGI
  • abnormal heart septum morphology / MGI
  • increased thymocyte apoptosis / MGI
  • pulmonary vascular congestion / MGI
  • liver vascular congestion / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • increased spinal cord apoptosis / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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