IMPC phenotypes (allele matching)
C57BL/6NTac-Sncaem1(IMPC)H/H
| Status | Available to order |
| EMMA ID | EM:11550 |
| International strain name | C57BL/6NTac-Sncaem1(IMPC)H/H |
| Alternative name | |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Sncaem1(IMPC)H |
| Gene/Transgene symbol | Snca |
Information from provider
| Provider | MRC, Medical Research Council |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | wild-type C57BL/6NTacUSA, heterozygous C57BL/6N |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Hereditary late-onset Parkinson disease / Orphanet_411602
- Parkinsonian-pyramidal syndrome / Orphanet_171695
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- impaired coordination / MGI
- reduced long term potentiation / MGI
- no abnormal phenotype detected / MGI
- decreased susceptibility to bacterial infection / MGI
- catalepsy / MGI
- no phenotypic analysis / MGI
- abnormal dopaminergic neuron morphology / MGI
- abnormal locomotor activation / MGI
- nervous system phenotype / MGI
- abnormal synaptic transmission / MGI
- abnormal miniature excitatory postsynaptic currents / MGI
- cellular phenotype / MGI
- behavior/neurological phenotype / MGI
- decreased dopamine level / MGI
- increased physiological sensitivity to xenobiotic / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- long stride length / MGI
- mortality/aging / MGI
- abnormal respiratory electron transport chain / MGI
- decreased dopaminergic neuron number / MGI
- decreased susceptibility to dopaminergic neuron neurotoxicity / MGI